-
Je něco špatně v tomto záznamu ?
Acute stimulation with symmetric biphasic pulses induces less ataxia compared to cathodic pulses in DBS for essential tremor
A. Boogers, J. Peeters, T. Van Bogaert, J. Rusz, C. Bogaert-Miclaus, G. Loret, P. De Vloo, W. Vandenberghe, B. Nuttin, M. Mc Laughlin
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, randomizované kontrolované studie, práce podpořená grantem
- MeSH
- ataxie etiologie MeSH
- dysartrie etiologie MeSH
- elektrody MeSH
- esenciální tremor * terapie etiologie MeSH
- hluboká mozková stimulace * škodlivé účinky MeSH
- lidé MeSH
- nuclei ventrales thalami chirurgie MeSH
- tremor etiologie MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
BACKGROUND: Symmetric biphasic pulses have been shown to acutely increase the therapeutic window of ventralis intermedius deep brain stimulation (Vim-DBS) for essential tremor (ET) compared to cathodic pulses. Acute supratherapeutic stimulation can induce ataxic side effects in Vim-DBS. OBJECTIVE: To investigate the effect on tremor, ataxia and dysarthria of 3 h of biphasic stimulation in patients with DBS for ET. METHODS: A randomized, doubled-blind, cross-over design was used to compare standard cathodic pulses with symmetric biphasic pulses (anode-first) during a 3-h period per pulse shape. During each 3-h period, all stimulation parameters were identical, except for the pulse shape. Tremor (Fahn-Tolosa-Marin Tremor Rating Scale), ataxia (International Cooperative Ataxia Rating Scale) and speech (acoustic and perceptual measures) were assessed hourly during the 3-h periods. RESULTS: Twelve ET patients were included. During the 3-h stimulation period, tremor control was equivalent between the two pulse shapes. Biphasic pulses elicited significantly less ataxia than cathodic pulses (p = 0.006). Diadochokinesis rate of speech was better for the biphasic pulse (p = 0.048), but other measures for dysarthria were not significantly different between the pulses. CONCLUSION: Symmetric biphasic pulses induce less ataxia than conventional pulses after 3 h of stimulation DBS in ET patients.
Department of Neurology AZ Sint Lucas Groenebriel 1 9000 Gent Belgium
Department of Neurology UZ Leuven Herestraat 49 3000 Leuven Belgium
Department of Neurosurgery UZ Leuven Herestraat 49 3000 Leuven Belgium
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc23011170
- 003
- CZ-PrNML
- 005
- 20230801132837.0
- 007
- ta
- 008
- 230718s2023 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.parkreldis.2023.105435 $2 doi
- 035 __
- $a (PubMed)37187082
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Boogers, Alexandra $u Exp ORL, Department of Neurosciences, The Leuven Brain Institute, KU Leuven, Herestraat 49, 3000, Leuven, Belgium; Department of Neurology, UZ Leuven, Herestraat 49, 3000, Leuven, Belgium
- 245 10
- $a Acute stimulation with symmetric biphasic pulses induces less ataxia compared to cathodic pulses in DBS for essential tremor / $c A. Boogers, J. Peeters, T. Van Bogaert, J. Rusz, C. Bogaert-Miclaus, G. Loret, P. De Vloo, W. Vandenberghe, B. Nuttin, M. Mc Laughlin
- 520 9_
- $a BACKGROUND: Symmetric biphasic pulses have been shown to acutely increase the therapeutic window of ventralis intermedius deep brain stimulation (Vim-DBS) for essential tremor (ET) compared to cathodic pulses. Acute supratherapeutic stimulation can induce ataxic side effects in Vim-DBS. OBJECTIVE: To investigate the effect on tremor, ataxia and dysarthria of 3 h of biphasic stimulation in patients with DBS for ET. METHODS: A randomized, doubled-blind, cross-over design was used to compare standard cathodic pulses with symmetric biphasic pulses (anode-first) during a 3-h period per pulse shape. During each 3-h period, all stimulation parameters were identical, except for the pulse shape. Tremor (Fahn-Tolosa-Marin Tremor Rating Scale), ataxia (International Cooperative Ataxia Rating Scale) and speech (acoustic and perceptual measures) were assessed hourly during the 3-h periods. RESULTS: Twelve ET patients were included. During the 3-h stimulation period, tremor control was equivalent between the two pulse shapes. Biphasic pulses elicited significantly less ataxia than cathodic pulses (p = 0.006). Diadochokinesis rate of speech was better for the biphasic pulse (p = 0.048), but other measures for dysarthria were not significantly different between the pulses. CONCLUSION: Symmetric biphasic pulses induce less ataxia than conventional pulses after 3 h of stimulation DBS in ET patients.
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a ataxie $x etiologie $7 D001259
- 650 12
- $a hluboká mozková stimulace $x škodlivé účinky $7 D046690
- 650 _2
- $a dysartrie $x etiologie $7 D004401
- 650 _2
- $a elektrody $7 D004566
- 650 12
- $a esenciální tremor $x terapie $x etiologie $7 D020329
- 650 _2
- $a výsledek terapie $7 D016896
- 650 _2
- $a tremor $x etiologie $7 D014202
- 650 _2
- $a nuclei ventrales thalami $x chirurgie $7 D020651
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a randomizované kontrolované studie $7 D016449
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Peeters, Jana $u Exp ORL, Department of Neurosciences, The Leuven Brain Institute, KU Leuven, Herestraat 49, 3000, Leuven, Belgium
- 700 1_
- $a Van Bogaert, Tine $u Exp ORL, Department of Neurosciences, The Leuven Brain Institute, KU Leuven, Herestraat 49, 3000, Leuven, Belgium
- 700 1_
- $a Rusz, Jan $u Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Technicka 2, 160 00, Prague 6, Czech Republic
- 700 1_
- $a Bogaert-Miclaus, Camelia $u Department of Neurology, AZ Sint-Lucas, Groenebriel 1, 9000, Gent, Belgium
- 700 1_
- $a Loret, Griet $u Department of Neurology, AZ Sint-Lucas, Groenebriel 1, 9000, Gent, Belgium
- 700 1_
- $a De Vloo, Philippe $u Department of Neurosurgery, UZ Leuven, Herestraat 49, 3000, Leuven, Belgium; Experimental Neurosurgery and Neuroanatomy, Department of Neurosciences, KU Leuven, Herestraat 49, 3000, Leuven, Belgium
- 700 1_
- $a Vandenberghe, Wim $u Department of Neurology, UZ Leuven, Herestraat 49, 3000, Leuven, Belgium; Laboratory for Parkinson Research, Department of Neurosciences, KU Leuven, Herestraat 49, 3000, Leuven, Belgium
- 700 1_
- $a Nuttin, Bart $u Department of Neurosurgery, UZ Leuven, Herestraat 49, 3000, Leuven, Belgium; Experimental Neurosurgery and Neuroanatomy, Department of Neurosciences, KU Leuven, Herestraat 49, 3000, Leuven, Belgium
- 700 1_
- $a Mc Laughlin, Myles $u Exp ORL, Department of Neurosciences, The Leuven Brain Institute, KU Leuven, Herestraat 49, 3000, Leuven, Belgium. Electronic address: myles.mclaughlin@kuleuven.be
- 773 0_
- $w MED00006198 $t Parkinsonism & related disorders $x 1873-5126 $g Roč. 111, č. - (2023), s. 105435
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/37187082 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20230718 $b ABA008
- 991 __
- $a 20230801132834 $b ABA008
- 999 __
- $a ok $b bmc $g 1963511 $s 1197435
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2023 $b 111 $c - $d 105435 $e 20230508 $i 1873-5126 $m Parkinsonism & related disorders $n Parkinsonism Relat Disord $x MED00006198
- LZP __
- $a Pubmed-20230718
