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High-grade non-intestinal type sinonasal adenocarcinoma with ETV6::NTRK3 fusion, distinct from secretory carcinoma by immunoprofile and morphology
N. Klubíčková, E. Mosaieby, N. Ptáková, A. Trinquet, M. Laé, V. Costes-Martineau, A. Skálová
Jazyk angličtina Země Německo
Typ dokumentu kazuistiky, časopisecké články
Grantová podpora
SVV260652
Ministerstvo Školství, Mládeže a Tělovýchovy
Cooperatio Program, research area SURG
Univerzita Karlova v Praze
NLK
ProQuest Central
od 2003-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2011-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 2003-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2003-01-01 do Před 1 rokem
- MeSH
- adenokarcinom * genetika patologie MeSH
- fúzní onkogenní proteiny genetika MeSH
- imunohistochemie MeSH
- karcinom * genetika patologie MeSH
- lidé MeSH
- nádorové biomarkery genetika MeSH
- nádory slinných žláz * genetika patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
We report 2 cases of high-grade sinonasal adenocarcinoma with a distinct morphological and immunohistochemical phenotype. Albeit histologically different from secretory carcinoma of the salivary glands, both tumors presented here share an ETV6::NTRK3 fusion. The highly cellular tumors were composed of solid and dense cribriform nests, often with comedo-like necroses in the center, and minor areas with papillary, microcystic, and trabecular formations without secretions, mostly located at the periphery of the lesion. The cells displayed high-grade features, with enlarged, crowded, and often vesicular nuclei with conspicuous nucleoli and brisk mitotic activity. The tumor cells were immunonegative for mammaglobin while showing immunopositivity for p40/p63, S100, SOX10, and GATA3, as well as for cytokeratins 7, 18, and 19. For the first time, we describe 2 cases of primary high-grade non-intestinal type adenocarcinomas of the nasal cavity, distinct from secretory carcinoma by morphology and immunoprofile, harboring the ETV6::NTRK3 fusion.
Bioptical Laboratory Pilsen Czech Republic
Department of Pathology Centre Henri Becquerel Rouen France
Department of Pathology Hopital Gui de Chauliac Montpellier France
Molecular Genetic Laboratory Bioptical Laboratory Pilsen Czech Republic
Citace poskytuje Crossref.org
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