Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

High-grade non-intestinal type sinonasal adenocarcinoma with ETV6::NTRK3 fusion, distinct from secretory carcinoma by immunoprofile and morphology

N. Klubíčková, E. Mosaieby, N. Ptáková, A. Trinquet, M. Laé, V. Costes-Martineau, A. Skálová

. 2023 ; 483 (2) : 187-195. [pub] 20230706

Jazyk angličtina Země Německo

Typ dokumentu kazuistiky, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc23016670

Grantová podpora
SVV260652 Ministerstvo Školství, Mládeže a Tělovýchovy
Cooperatio Program, research area SURG Univerzita Karlova v Praze

E-zdroje Online Plný text

NLK ProQuest Central od 2003-01-01 do Před 1 rokem
Medline Complete (EBSCOhost) od 2011-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest) od 2003-01-01 do Před 1 rokem
Health & Medicine (ProQuest) od 2003-01-01 do Před 1 rokem

Odkazy

PubMed 37415052
DOI 10.1007/s00428-023-03587-6
Knihovny.cz E-zdroje

We report 2 cases of high-grade sinonasal adenocarcinoma with a distinct morphological and immunohistochemical phenotype. Albeit histologically different from secretory carcinoma of the salivary glands, both tumors presented here share an ETV6::NTRK3 fusion. The highly cellular tumors were composed of solid and dense cribriform nests, often with comedo-like necroses in the center, and minor areas with papillary, microcystic, and trabecular formations without secretions, mostly located at the periphery of the lesion. The cells displayed high-grade features, with enlarged, crowded, and often vesicular nuclei with conspicuous nucleoli and brisk mitotic activity. The tumor cells were immunonegative for mammaglobin while showing immunopositivity for p40/p63, S100, SOX10, and GATA3, as well as for cytokeratins 7, 18, and 19. For the first time, we describe 2 cases of primary high-grade non-intestinal type adenocarcinomas of the nasal cavity, distinct from secretory carcinoma by morphology and immunoprofile, harboring the ETV6::NTRK3 fusion.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23016670
003      
CZ-PrNML
005      
20231026105633.0
007      
ta
008      
231013s2023 gw f 000 0|eng||
009      
AR
024    7_
$a 10.1007/s00428-023-03587-6 $2 doi
035    __
$a (PubMed)37415052
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gw
100    1_
$a Klubíčková, Natálie $u Department of Pathology, Faculty of Medicine in Pilsen and University Hospital Plzen,, Charles University, Alej Svobody 80, 323 00, Pilsen, Czech Republic. klubickova@biopticka.cz $u Bioptical Laboratory, Pilsen, Czech Republic. klubickova@biopticka.cz $1 https://orcid.org/0000000244075544
245    10
$a High-grade non-intestinal type sinonasal adenocarcinoma with ETV6::NTRK3 fusion, distinct from secretory carcinoma by immunoprofile and morphology / $c N. Klubíčková, E. Mosaieby, N. Ptáková, A. Trinquet, M. Laé, V. Costes-Martineau, A. Skálová
520    9_
$a We report 2 cases of high-grade sinonasal adenocarcinoma with a distinct morphological and immunohistochemical phenotype. Albeit histologically different from secretory carcinoma of the salivary glands, both tumors presented here share an ETV6::NTRK3 fusion. The highly cellular tumors were composed of solid and dense cribriform nests, often with comedo-like necroses in the center, and minor areas with papillary, microcystic, and trabecular formations without secretions, mostly located at the periphery of the lesion. The cells displayed high-grade features, with enlarged, crowded, and often vesicular nuclei with conspicuous nucleoli and brisk mitotic activity. The tumor cells were immunonegative for mammaglobin while showing immunopositivity for p40/p63, S100, SOX10, and GATA3, as well as for cytokeratins 7, 18, and 19. For the first time, we describe 2 cases of primary high-grade non-intestinal type adenocarcinomas of the nasal cavity, distinct from secretory carcinoma by morphology and immunoprofile, harboring the ETV6::NTRK3 fusion.
650    _2
$a lidé $7 D006801
650    12
$a adenokarcinom $x genetika $x patologie $7 D000230
650    _2
$a nádorové biomarkery $x genetika $7 D014408
650    12
$a karcinom $x genetika $x patologie $7 D002277
650    _2
$a imunohistochemie $7 D007150
650    _2
$a fúzní onkogenní proteiny $x genetika $7 D015514
650    12
$a nádory slinných žláz $x genetika $x patologie $7 D012468
655    _2
$a kazuistiky $7 D002363
655    _2
$a časopisecké články $7 D016428
700    1_
$a Mosaieby, Elaheh $u Department of Pathology, Faculty of Medicine in Pilsen and University Hospital Plzen,, Charles University, Alej Svobody 80, 323 00, Pilsen, Czech Republic $u Molecular-Genetic Laboratory, Bioptical Laboratory, Pilsen, Czech Republic
700    1_
$a Ptáková, Nikola $u Molecular-Genetic Laboratory, Bioptical Laboratory, Pilsen, Czech Republic $u Department of Biology and Medical Genetics, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic
700    1_
$a Trinquet, Aude $u Department of Pathology, Hopital Gui de Chauliac, Montpellier, France
700    1_
$a Laé, Marick $u Department of Pathology, Centre Henri Becquerel, Rouen, France
700    1_
$a Costes-Martineau, Valérie $u Department of Pathology, Hopital Gui de Chauliac, Montpellier, France
700    1_
$a Skálová, Alena $u Department of Pathology, Faculty of Medicine in Pilsen and University Hospital Plzen,, Charles University, Alej Svobody 80, 323 00, Pilsen, Czech Republic $u Bioptical Laboratory, Pilsen, Czech Republic
773    0_
$w MED00004660 $t Virchows Archiv : an international journal of pathology $x 1432-2307 $g Roč. 483, č. 2 (2023), s. 187-195
856    41
$u https://pubmed.ncbi.nlm.nih.gov/37415052 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20231013 $b ABA008
991    __
$a 20231026105628 $b ABA008
999    __
$a ok $b bmc $g 2000282 $s 1203032
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2023 $b 483 $c 2 $d 187-195 $e 20230706 $i 1432-2307 $m Virchows Archiv $n Virchows Arch $x MED00004660
GRA    __
$a SVV260652 $p Ministerstvo Školství, Mládeže a Tělovýchovy
GRA    __
$a Cooperatio Program, research area SURG $p Univerzita Karlova v Praze
LZP    __
$a Pubmed-20231013

Najít záznam

Citační ukazatele

Možnosti archivace