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Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe
L. Rodriguez Martin, L. Gilles, E. Helte, A. Åkesson, J. Tägt, A. Covaci, AK. Sakhi, A. Van Nieuwenhuyse, A. Katsonouri, AM. Andersson, AC. Gutleb, B. Janasik, B. Appenzeller, C. Gabriel, C. Thomsen, D. Mazej, D. Sarigiannis, E. Anastasi, F....
Status neindexováno Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
PubMed Central od 2015
Europe PubMed Central od 2015
ProQuest Central od 2013-01-01
Open Access Digital Library od 2013-01-01
ROAD: Directory of Open Access Scholarly Resources od 2013
Odkazy
PubMed
37888670
DOI
10.3390/toxics11100819
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
Human biomonitoring (HBM) data in Europe are often fragmented and collected in different EU countries and sampling periods. Exposure levels for children and adult women in Europe were evaluated over time. For the period 2000-2010, literature and aggregated data were collected in a harmonized way across studies. Between 2011-2012, biobanked samples from the DEMOCOPHES project were used. For 2014-2021, HBM data were generated within the HBM4EU Aligned Studies. Time patterns on internal exposure were evaluated visually and statistically using the 50th and 90th percentiles (P50/P90) for phthalates/DINCH and organophosphorus flame retardants (OPFRs) in children (5-12 years), and cadmium, bisphenols and polycyclic aromatic hydrocarbons (PAHs) in women (24-52 years). Restricted phthalate metabolites show decreasing patterns for children. Phthalate substitute, DINCH, shows a non-significant increasing pattern. For OPFRs, no trends were statistically significant. For women, BPA shows a clear decreasing pattern, while substitutes BPF and BPS show an increasing pattern coinciding with the BPA restrictions introduced. No clear patterns are observed for PAHs or cadmium. Although the causal relations were not studied as such, exposure levels to chemicals restricted at EU level visually decreased, while the levels for some of their substitutes increased. The results support policy efficacy monitoring and the policy-supportive role played by HBM.
Centre for Health and Environment National Institute of Public Health 100 00 Prague Czech Republic
Department of Environment and Health Public Health Authority 83105 Bratislava Slovakia
Department of Environmental and Occupational Health Santé Publique France 94410 Saint Maurice France
Faculty of Food Science and Nutrition University of Iceland Hofsvallagata 53 107 Reykjavik Iceland
Finnish Institute for Health and Welfare 00271 Helsinki Finland
Institute of Environmental Medicine Karolinska Institutet 17177 Stockholm Sweden
Jožef Stefan Institute 1000 Ljubljana Slovenia
Laboratoire National de Santé Rue Louis Rech 1 3555 Dudelange Luxembourg
Luxembourg Institute of Health 1445 Strassen Luxembourg
Luxembourg Institute of Science and Technology 4362 Esch sur Alzette Luxembourg
National Centre for Environmental Health Instituto de Salud Carlos 3 28220 Majadahonda Spain
National Public Health Center Albert Florian 2 6 1097 Budapest Hungary
Nofer Institute of Occupational Medicine 91 348 Lodz Poland
Norwegian Institute of Public Health 0456 Oslo Norway
RECETOX Faculty of Science Masaryk University Kotlarska 2 625 00 Brno Czech Republic
Section of Environmental Health University of Copenhagen 1165 Copenhagen Denmark
State General Laboratory Ministry of Health 2081 Nicosia Cyprus
Swiss Tropical and Public Health Institute Kreuzstrasse 2 4123 Allschwil Switzerland
Toxicological Centre University of Antwerp Universiteitsplein 1 2610 Antwerp Belgium
UKHSA UK Health Security Agency Harwell Science Park Chilton OX11 0RQ UK
VITO Health Flemish Institute for Technological Research 2400 Mol Belgium
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