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Systemic Immune-Inflammation Index in Patients Treated With First-Line Immune Combinations for Metastatic Renal Cell Carcinoma: Insights From the ARON-1 Study
FSM. Monteiro, O. Fiala, F. Massari, ZW. Myint, J. Kopecky, J. Kucharz, T. Büttner, E. Grande, MT. Bourlon, J. Molina-Cerrillo, R. Pichler, T. Buchler, E. Seront, J. Ansari, A. Bamias, D. Bhuva, N. Vau, C. Porta, AP. Fay, M. Santoni
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Odkazy
PubMed
38087702
DOI
10.1016/j.clgc.2023.11.013
Knihovny.cz E-zdroje
- MeSH
- analýza přežití MeSH
- karcinom z renálních buněk * patologie MeSH
- lidé MeSH
- nádory ledvin * patologie MeSH
- prognóza MeSH
- retrospektivní studie MeSH
- zánět patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Systemic treatment with immune combinations is the gold standard for metastatic renal cell carcinoma (mRCC) worldwide. The systemic immune-inflammation index (SII) is a prognostic marker for several types of malignant neoplasms, including mRCC, in the era of tyrosine kinase inhibitor (TKI) treatment. Data regarding the prognostic value of the SII in patients with mRCC treated with immunotherapy are scarce and controversial. METHODS: We retrospectively collected the data of patients with mRCC from 56 centers in 18 countries. SII (Platelet × Neutrophil/Lymphocyte count) was calculated prior to the first systemic treatment and cut-off was defined by a survival receiver operating characteristic (ROC) analysis. The primary objective of our retrospective study was to assess the outcomes of patients treated with first-line immunotherapy. RESULTS: Data from 1034 mRCC patients was collected and included in this analysis. The SII cut-off value was 1265. After a follow-up of 26.7 months, and the overall survival (OS) and progression-free survival (PFS) were 39.8 and 15.7 months, respectively. According to SII (low vs. high), patients with low-SII had longer OS (55.7 vs. 22.2 months, P < .001), better PFS (20.8 vs. 8.5 months, P < .001), and higher overall response rate (52 vs. 37%, P = .033). CONCLUSION: A high SII is associated with poor oncological outcomes in patients with mRCC. SII could be an easily accessible prognostic indicator for use in clinical practice.
Biomedical Center Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Department of Biomedical Sciences and Human Oncology University of Bari Aldo Moro Bari Italy
Department of Medical Oncology Army Hospital Research and Referral New Delhi India
Department of Medical Oncology Centre Hospitalier de Jolimont Haine Saint Paul Belgium
Department of Medical Oncology MD Anderson Cancer Center Madrid Madrid Spain
Department of Medical Oncology University Hospital Ramón y Cajal Madrid Spain
Department of Urology Medical University of Innsbruck Innsbruck Austria
Department of Urology University Hospital Bonn 53127 Bonn Germany
Hospital Sirio Libanês Brasilia DF Brazil
Latin American Cooperative Oncology Group LACOG Porto Alegre RS Brazil
Markey Cancer Center University of Kentucky Lexington KY
Medical Oncology IRCCS Azienda Ospedaliero Universitaria di Bologna Bologna Italia
Medical Oncology Tawam Hospital Al Ain United Arab Emirates
Oncology Unit Macerata Hospital Macerata Italy
PUCRS School of Medicine Porto Alegre RS Brazil
Urologic Oncology Champalimaud Clinical Center Lisbon Portugal
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