-
Something wrong with this record ?
Variant ALK-fusion positive anaplastic large cell lymphoma (ALCL): A population-based paediatric study of the NHL-BFM study group
J. Luedersen, UZ. Stadt, J. Richter, I. Oschlies, W. Klapper, A. Rosenwald, M. Kalinova, I. Simonitsch-Klupp, R. Siebert, M. Zimmermann, M. Qi, J. Nakel, K. Scheinemann, F. Knörr, A. Attarbaschi, E. Kabickova, W. Woessmann, C. Damm-Welk
Language English Country England, Great Britain
Document type Journal Article
Grant support
Hamburger Stiftung zur Foerderung der Krebsbekaempfung
Juli Harnack scholarship of the Foerdergemeinschaft Kinderkrebszentrum Hamburg e.V.
KinderkrebsInitiative Buchholz, Holm-Seppensen
Deutsche Kinderkrebsstiftung
PubMed
38279625
DOI
10.1111/bjh.19308
Knihovny.cz E-resources
- MeSH
- Anaplastic Lymphoma Kinase * genetics analysis MeSH
- Lymphoma, Large-Cell, Anaplastic * genetics pathology MeSH
- Child MeSH
- Oncogene Proteins, Fusion genetics MeSH
- Nuclear Proteins genetics metabolism MeSH
- Infant MeSH
- Humans MeSH
- Adolescent MeSH
- Nucleophosmin * MeSH
- Child, Preschool MeSH
- Prognosis MeSH
- Tropomyosin MeSH
- Check Tag
- Child MeSH
- Infant MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
Frequency, distribution and prognostic meaning of ALK-partner genes other than NPM1 in ALK-positive anaplastic large-cell lymphoma (ALCL) are unknown. Forty-nine of 316 ALCL diagnosed in the NHL-BFM study group showed no nuclear ALK expression suggestive of a variant ALK-partner; 41 were analysed by genomic capture high-throughput sequencing or specific RT-PCRs. NPM1::ALK was detected in 13 cases. Among the 28 patients with a non-NPM1::ALK-fusion partner, ATIC (n = 8; 29%) and TPM3 (n = 9; 32%) were the most common. Five of eight patients with ATIC::ALK-positive ALCL relapsed, none of nine with TPM3::ALK. Variant ALK-partners are rare and potentially associated with different prognoses.
Bioinformatics Core University Medical Centre Hamburg Eppendorf Hamburg Germany
Department of Pathology Medical University of Vienna Vienna Austria
Department of Pathology University of Wuerzburg Wuerzburg Germany
Faculty of Health Science and Medicine University of Lucerne Lucerne Switzerland
Institute of Human Genetics Ulm University and Ulm University Medical Centre Ulm Germany
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc24014184
- 003
- CZ-PrNML
- 005
- 20240905133954.0
- 007
- ta
- 008
- 240725s2024 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1111/bjh.19308 $2 doi
- 035 __
- $a (PubMed)38279625
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Luedersen, Jette $u Paediatric Haematology and Oncology and NHL-BFM Study Centre, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
- 245 10
- $a Variant ALK-fusion positive anaplastic large cell lymphoma (ALCL): A population-based paediatric study of the NHL-BFM study group / $c J. Luedersen, UZ. Stadt, J. Richter, I. Oschlies, W. Klapper, A. Rosenwald, M. Kalinova, I. Simonitsch-Klupp, R. Siebert, M. Zimmermann, M. Qi, J. Nakel, K. Scheinemann, F. Knörr, A. Attarbaschi, E. Kabickova, W. Woessmann, C. Damm-Welk
- 520 9_
- $a Frequency, distribution and prognostic meaning of ALK-partner genes other than NPM1 in ALK-positive anaplastic large-cell lymphoma (ALCL) are unknown. Forty-nine of 316 ALCL diagnosed in the NHL-BFM study group showed no nuclear ALK expression suggestive of a variant ALK-partner; 41 were analysed by genomic capture high-throughput sequencing or specific RT-PCRs. NPM1::ALK was detected in 13 cases. Among the 28 patients with a non-NPM1::ALK-fusion partner, ATIC (n = 8; 29%) and TPM3 (n = 9; 32%) were the most common. Five of eight patients with ATIC::ALK-positive ALCL relapsed, none of nine with TPM3::ALK. Variant ALK-partners are rare and potentially associated with different prognoses.
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a anaplastický velkobuněčný lymfom $x genetika $x patologie $7 D017728
- 650 _2
- $a dítě $7 D002648
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 12
- $a anaplastická lymfomová kináza $x genetika $x analýza $7 D000077548
- 650 _2
- $a mladiství $7 D000293
- 650 12
- $a nukleofosmin $7 D000090243
- 650 _2
- $a předškolní dítě $7 D002675
- 650 _2
- $a fúzní onkogenní proteiny $x genetika $7 D015514
- 650 _2
- $a prognóza $7 D011379
- 650 _2
- $a jaderné proteiny $x genetika $x metabolismus $7 D009687
- 650 _2
- $a kojenec $7 D007223
- 650 _2
- $a tropomyosin $7 D014335
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Stadt, Udo Zur $u Paediatric Haematology and Oncology and CoALL Study Centre, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
- 700 1_
- $a Richter, Julia $u Department of Pathology, Haematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Kiel, Germany $1 https://orcid.org/0000000295434084
- 700 1_
- $a Oschlies, Ilske $u Department of Pathology, Haematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Kiel, Germany
- 700 1_
- $a Klapper, Wolfram $u Department of Pathology, Haematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Kiel, Germany $1 https://orcid.org/0000000172084117 $7 xx0317360
- 700 1_
- $a Rosenwald, Andreas $u Department of Pathology, University of Wuerzburg, Wuerzburg, Germany
- 700 1_
- $a Kalinova, Marketa $u Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University Prague and University Hospital in Motol, Prague, Czech Republic $u Department of Pathology, 3rd Faculty of Medicine, Charles University Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic
- 700 1_
- $a Simonitsch-Klupp, Ingrid $u Department of Pathology, Medical University of Vienna, Vienna, Austria
- 700 1_
- $a Siebert, Reiner $u Institute of Human Genetics, Ulm University & Ulm University Medical Centre, Ulm, Germany
- 700 1_
- $a Zimmermann, Martin $u Department of Paediatric Haematology and Oncology, Hannover Medical School, and NHL-BFM Study Centre, Hannover, Germany
- 700 1_
- $a Qi, Minyue $u Bioinformatics Core, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
- 700 1_
- $a Nakel, Jacqueline $u Leibniz Institute of Virology (LIV), Hamburg, Germany
- 700 1_
- $a Scheinemann, Katrin $u Division of Paediatric Haematology/Oncology, Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland $u Faculty of Health Science and Medicine, University of Lucerne, Lucerne, Switzerland $u Department of Paediatrics, McMaster Children's Hospital and McMaster University, Hamilton, Ontario, Canada
- 700 1_
- $a Knörr, Fabian $u Paediatric Haematology and Oncology and NHL-BFM Study Centre, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany $u Mildred Scheel Cancer Career Centre HaTriCS4, University Medical Centre Hamburg- Eppendorf, Hamburg, Germany
- 700 1_
- $a Attarbaschi, Andishe $u Department of Paediatric Haematology and Oncology, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria $u St. Anna Children's Cancer Research Institute, Vienna, Austria $1 https://orcid.org/0000000292856898
- 700 1_
- $a Kabickova, Edita $u Department of Pediatric Hematology and Oncology, Charles University Prague and University Hospital Motol, Prague, Czech Republic
- 700 1_
- $a Woessmann, Wilhelm $u Paediatric Haematology and Oncology and NHL-BFM Study Centre, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany $1 https://orcid.org/0000000263150888
- 700 1_
- $a Damm-Welk, Christine $u Paediatric Haematology and Oncology and NHL-BFM Study Centre, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany $1 https://orcid.org/0000000282214197
- 773 0_
- $w MED00009374 $t British journal of haematology $x 1365-2141 $g Roč. 204, č. 5 (2024), s. 1894-1898
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/38279625 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20240725 $b ABA008
- 991 __
- $a 20240905133948 $b ABA008
- 999 __
- $a ok $b bmc $g 2143773 $s 1226050
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2024 $b 204 $c 5 $d 1894-1898 $e 20240126 $i 1365-2141 $m British journal of haematology $n Br J Haematol $x MED00009374
- GRA __
- $p Hamburger Stiftung zur Foerderung der Krebsbekaempfung
- GRA __
- $p Juli Harnack scholarship of the Foerdergemeinschaft Kinderkrebszentrum Hamburg e.V.
- GRA __
- $p KinderkrebsInitiative Buchholz, Holm-Seppensen
- GRA __
- $p Deutsche Kinderkrebsstiftung
- LZP __
- $a Pubmed-20240725
