Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

On the utility of cerebrospinal fluid biomarkers in canine neurological disorders

T. Smolek, Z. Vince-Kazmerova, J. Hanes, E. Stevens, V. Palus, I. Hajek, S. Katina, P. Novak, N. Zilka

. 2024 ; 14 (1) : 24129. [pub] 20241015

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc25003866

Grantová podpora
2/0127/22 VEGA
APVV-18-0515 Agentúra na Podporu Výskumu a Vývoja
APVV-18-0515 Agentúra na Podporu Výskumu a Vývoja

The cerebral biomarkers, neurofilament light chain (NfL), amyloid-β, tau, and neuron specific enolase (NSE) reflect a wide spectrum of neurological damage in the brain and spinal cord. With this study, we aimed to assess whether these biomarkers hold any potential diagnostic value for the three most common canine neurological diseases. Canines suffering from meningoencephalitis of unknown origin (MUO), brain tumors, and selected non-infectious myelopathies were included. For each diagnosis, we analyzed these biomarkers in the cerebrospinal fluid collected via cranial puncture from the cisterna magna. Elevated levels of CSF tau, NfL, and NSE were observed in MUO, with all three biomarkers being intercorrelated. Tau and NSE were increased while amyloid-β was decreased in dogs suffering from tumors. In contrast, no biomarker changes were observed in dogs with myelopathies. Covariates such as age, sex, or castration had minimal impact. CSF biomarkers may reflect molecular changes related to MUO and tumors, but not to non-infectious myelopathies. The combination of NfL, tau, and NSE may represent useful biomarkers for MUO as they reflect the same pathology and are not influenced by age.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25003866
003      
CZ-PrNML
005      
20250206104746.0
007      
ta
008      
250121s2024 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s41598-024-73812-y $2 doi
035    __
$a (PubMed)39406773
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Smolek, Tomas $u Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská Cesta 9, Bratislava, Slovak Republic $u Neuroimmunology Institute, n.p.o., Dvořákovo nábrežie 7527/10, 811 02, Bratislava, Slovak Republic
245    10
$a On the utility of cerebrospinal fluid biomarkers in canine neurological disorders / $c T. Smolek, Z. Vince-Kazmerova, J. Hanes, E. Stevens, V. Palus, I. Hajek, S. Katina, P. Novak, N. Zilka
520    9_
$a The cerebral biomarkers, neurofilament light chain (NfL), amyloid-β, tau, and neuron specific enolase (NSE) reflect a wide spectrum of neurological damage in the brain and spinal cord. With this study, we aimed to assess whether these biomarkers hold any potential diagnostic value for the three most common canine neurological diseases. Canines suffering from meningoencephalitis of unknown origin (MUO), brain tumors, and selected non-infectious myelopathies were included. For each diagnosis, we analyzed these biomarkers in the cerebrospinal fluid collected via cranial puncture from the cisterna magna. Elevated levels of CSF tau, NfL, and NSE were observed in MUO, with all three biomarkers being intercorrelated. Tau and NSE were increased while amyloid-β was decreased in dogs suffering from tumors. In contrast, no biomarker changes were observed in dogs with myelopathies. Covariates such as age, sex, or castration had minimal impact. CSF biomarkers may reflect molecular changes related to MUO and tumors, but not to non-infectious myelopathies. The combination of NfL, tau, and NSE may represent useful biomarkers for MUO as they reflect the same pathology and are not influenced by age.
650    _2
$a zvířata $7 D000818
650    _2
$a psi $7 D004285
650    12
$a biologické markery $x mozkomíšní mok $7 D015415
650    12
$a nemoci psů $x mozkomíšní mok $x diagnóza $7 D004283
650    12
$a proteiny tau $x mozkomíšní mok $7 D016875
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a ženské pohlaví $7 D005260
650    12
$a neurofilamentové proteiny $x mozkomíšní mok $7 D016900
650    _2
$a fosfopyruváthydratasa $x mozkomíšní mok $7 D010751
650    _2
$a amyloidní beta-protein $x mozkomíšní mok $7 D016229
650    _2
$a meningoencefalitida $x mozkomíšní mok $x veterinární $x diagnóza $7 D008590
650    _2
$a nemoci nervového systému $x mozkomíšní mok $x veterinární $x diagnóza $7 D009422
650    _2
$a nádory mozku $x mozkomíšní mok $x veterinární $7 D001932
655    _2
$a časopisecké články $7 D016428
700    1_
$a Vince-Kazmerova, Zuzana $u Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská Cesta 9, Bratislava, Slovak Republic
700    1_
$a Hanes, Jozef $u Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská Cesta 9, Bratislava, Slovak Republic
700    1_
$a Stevens, Eva $u Axon Neuroscience R&D Services SE, Dvořakovo Nabrezie 10, Bratislava, Slovak Republic
700    1_
$a Palus, Viktor $u Neurovet -Referral Center for Veterinary Neurology, Bratislavska 2196/32, Trencin, Slovak Republic
700    1_
$a Hajek, Ivo $u Small Animal Referral Centre Sibra, Na Vrátkach 13, Bratislava, Slovak Republic
700    1_
$a Katina, Stanislav $u Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská Cesta 9, Bratislava, Slovak Republic $u Institute of Mathematics and Statistics, Masaryk University, Kotlářská 267/2, 611 37, Brno, Czech Republic
700    1_
$a Novak, Petr $u Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská Cesta 9, Bratislava, Slovak Republic. petr.novak@savba.sk
700    1_
$a Zilka, Norbert $u Institute of Neuroimmunology, Slovak Academy of Sciences, Dúbravská Cesta 9, Bratislava, Slovak Republic $u Neuroimmunology Institute, n.p.o., Dvořákovo nábrežie 7527/10, 811 02, Bratislava, Slovak Republic
773    0_
$w MED00182195 $t Scientific reports $x 2045-2322 $g Roč. 14, č. 1 (2024), s. 24129
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39406773 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250121 $b ABA008
991    __
$a 20250206104741 $b ABA008
999    __
$a ok $b bmc $g 2263559 $s 1239873
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 14 $c 1 $d 24129 $e 20241015 $i 2045-2322 $m Scientific reports $n Sci Rep $x MED00182195
GRA    __
$a 2/0127/22 $p VEGA
GRA    __
$a APVV-18-0515 $p Agentúra na Podporu Výskumu a Vývoja
GRA    __
$a APVV-18-0515 $p Agentúra na Podporu Výskumu a Vývoja
LZP    __
$a Pubmed-20250121

Najít záznam

Citační ukazatele

Možnosti archivace