Admin or Manager login required
Admin or Manager login required
Admin or Manager login required
Admin or Manager login required
Admin or Manager login required
Admin or Manager login required
Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Intestinal fatty acid-binding protein as a marker of prognosis and non-occlusive mesenteric ischemia in refractory cardiac arrest patients: a pilot study

J. Smalcova, LH. Brodska, J. Suen, Z. Vanickova, P. Kavalkova, N. White, B. Kolosova, H. Nonaka, J. Pudil, E. Svobodova, M. Balik, J. Malik, J. Belohlavek

. 2025 ; 24 (-) : 100972. [pub] 20250505

Status neindexováno Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc25014110

BACKGROUND: The neurological prognostication is crucial for the management of refractory out-of-hospital cardiac arrest (OHCA) patients. Despite treatment advances, ischemia-reperfusion brain injury remains a critical factor affecting neurological outcomes. This study evaluated the utility of intestinal fatty acid-binding protein (I-FABP) and its relationship with non-occlusive mesenteric ischemia (NOMI) for neurological prognostication, comparing patients with refractory cardiac arrest treated with extracorporeal cardiopulmonary resuscitation (ECPR) compared to those treated with conventional CPR. METHODS: This is a single-center prospective pilot study. We compared I-FABP levels in OHCA patients recruited from June 2022 to October 2023. Blood samples for I-FABP examination were collected at admission, 24, and 48 h and analyzed against 30-day neurological outcomes and NOMI occurrence. ROC analysis determined I-FABP cut-off values for predicting poor neurological outcomes (Cerebral Performance Category (CPC) 3-5) in ECPR and CPR groups. RESULTS: Among the 68 patients admitted for OHCA, 22 received ECPR and 46 conventional CPR. I-FABP cut-off values for predicting poor neurological outcomes were: at admission > 0.95 ng/mL for ECPR vs. 1.64 ng/mL for CPR (AUC 0.55 vs. 0.38); at 24 h > 0.04 ng/mL vs. 0.4 ng/mL (AUC 0.7 vs. 0.51); at 48 h > 0.18 ng/mL vs. 0.53 ng/mL (AUC 0.77 vs. 0.41). However, compared to NSE AUCs, I-FABP showed significantly worse outcomes prediction in all time points.I-FABP was unreliable in predicting neurological outcomes and also showed no consistent elevation in NOMI patients. CONCLUSION: Compared to neuron-specific enolase, I-FABP does not appear to be a predictor of outcome in patients with refractory cardiac arrest. Clinical manifestations of NOMI are not consistently associated with elevated I-FABP levels.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25014110
003      
CZ-PrNML
005      
20250905141452.0
007      
ta
008      
250701e20250505ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.resplu.2025.100972 $2 doi
035    __
$a (PubMed)40486105
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Smalcova, Jana $u Critical Care Research Group, Brisbane, Queensland, Australia $u First Faculty of Medicine, Charles University, Prague, Czech Republic
245    10
$a Intestinal fatty acid-binding protein as a marker of prognosis and non-occlusive mesenteric ischemia in refractory cardiac arrest patients: a pilot study / $c J. Smalcova, LH. Brodska, J. Suen, Z. Vanickova, P. Kavalkova, N. White, B. Kolosova, H. Nonaka, J. Pudil, E. Svobodova, M. Balik, J. Malik, J. Belohlavek
520    9_
$a BACKGROUND: The neurological prognostication is crucial for the management of refractory out-of-hospital cardiac arrest (OHCA) patients. Despite treatment advances, ischemia-reperfusion brain injury remains a critical factor affecting neurological outcomes. This study evaluated the utility of intestinal fatty acid-binding protein (I-FABP) and its relationship with non-occlusive mesenteric ischemia (NOMI) for neurological prognostication, comparing patients with refractory cardiac arrest treated with extracorporeal cardiopulmonary resuscitation (ECPR) compared to those treated with conventional CPR. METHODS: This is a single-center prospective pilot study. We compared I-FABP levels in OHCA patients recruited from June 2022 to October 2023. Blood samples for I-FABP examination were collected at admission, 24, and 48 h and analyzed against 30-day neurological outcomes and NOMI occurrence. ROC analysis determined I-FABP cut-off values for predicting poor neurological outcomes (Cerebral Performance Category (CPC) 3-5) in ECPR and CPR groups. RESULTS: Among the 68 patients admitted for OHCA, 22 received ECPR and 46 conventional CPR. I-FABP cut-off values for predicting poor neurological outcomes were: at admission > 0.95 ng/mL for ECPR vs. 1.64 ng/mL for CPR (AUC 0.55 vs. 0.38); at 24 h > 0.04 ng/mL vs. 0.4 ng/mL (AUC 0.7 vs. 0.51); at 48 h > 0.18 ng/mL vs. 0.53 ng/mL (AUC 0.77 vs. 0.41). However, compared to NSE AUCs, I-FABP showed significantly worse outcomes prediction in all time points.I-FABP was unreliable in predicting neurological outcomes and also showed no consistent elevation in NOMI patients. CONCLUSION: Compared to neuron-specific enolase, I-FABP does not appear to be a predictor of outcome in patients with refractory cardiac arrest. Clinical manifestations of NOMI are not consistently associated with elevated I-FABP levels.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
700    1_
$a Brodska, Lahoda Helena $u Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
700    1_
$a Suen, Jacky $u Critical Care Research Group, Brisbane, Queensland, Australia
700    1_
$a Vanickova, Zdislava $u Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
700    1_
$a Kavalkova, Petra $u 2nd Department of Cardiovascular Medicine, General University Hospital in Prague, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
700    1_
$a White, Nicole $u Critical Care Research Group, Brisbane, Queensland, Australia
700    1_
$a Kolosova, Barbora $u 3rd Department of Internal Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic
700    1_
$a Nonaka, Hideaki $u Critical Care Research Group, Brisbane, Queensland, Australia
700    1_
$a Pudil, Jan $u 2nd Department of Cardiovascular Medicine, General University Hospital in Prague, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
700    1_
$a Svobodova, Eva $u Department of Anesthesiology and Intensive Care Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic
700    1_
$a Balik, Martin $u Department of Anesthesiology and Intensive Care Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic
700    1_
$a Malik, Jan $u 3rd Department of Internal Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic
700    1_
$a Belohlavek, Jan $u 2nd Department of Cardiovascular Medicine, General University Hospital in Prague, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic $u Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland
773    0_
$w MED00209367 $t Resuscitation plus $x 2666-5204 $g Roč. 24 (20250505), s. 100972
856    41
$u https://pubmed.ncbi.nlm.nih.gov/40486105 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250701 $b ABA008
991    __
$a 20250905141440 $b ABA008
999    __
$a ok $b bmc $g 2387965 $s 1251230
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2025 $b 24 $c - $d 100972 $e 20250505 $i 2666-5204 $m Resuscitation plus $n Resusc Plus $x MED00209367
LZP    __
$a Pubmed-20250701

Najít záznam

Citační ukazatele

Možnosti archivace