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Determination of paraoxonase activity and prooxidant-antioxidant balance in the brain tissue of rats following subacute administration of different K-oximes
V. Jaćević, J. Grujić-Milanović, Z. Milovanović, S. Milanović, L. Nežić, L. Amidžić, N. Vojinović, B. Marković, V. Dobričić, P. Milosavljević, E. Nepovimova, K. Kuča
Language English Country Ireland
Document type Journal Article
- MeSH
- Antioxidants * metabolism MeSH
- Aryldialkylphosphatase * metabolism MeSH
- Nitrites metabolism MeSH
- Rats MeSH
- Brain * drug effects metabolism enzymology MeSH
- Oximes * pharmacology administration & dosage MeSH
- Rats, Wistar MeSH
- Sulfhydryl Compounds metabolism MeSH
- Superoxides metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
This study aimed to determine the paraoxonase activity and prooxidant-antioxidant balance in the brain tissue of Wistar rats following subacute treatment with selected K-oximes. Each K-oxime was administered intramuscularly (0.1 LD50/kg) twice per week for four weeks, and 7 days after the last treatment, the paraoxonase activity (PON1), the prooxidant-antioxidant balance (PAB), the levels of superoxide anion radical (O2•-), the concentration of nitrite (NO2-) and the content of free protein thiol groups in the brain homogenates were evaluated. The PON1 and PAB activity were significantly reduced in almost all oxime-treated groups (p < 0.01 and p < 0.001, respectively). The concentrations of O2•- were significantly increased in the obidoxime-, K048-, K074- and K075-treated groups (p < 0.001), while the levels of NO2- was significantly decreased in asoxime-, obidoxime-, K074 and K075-treated rats (p < 0.01, p < 0.001, respectively). The content of Thiol groups was significantly elevated in all oxime-treated groups (p < 0.001). Continuing our previously published data, these results confirmed that applied K-oximes improved the oxidative status and further harmful systemic effects of rats after subacute administration.
Biomedical Research Center University Hospital Hradec Kralove 50005 Hradec Kralove Czech Republic
Special Police Unit Ministry of Interior Trebevićka 12 A 11 030 Belgrade Serbia
Veterinary Services Center Military Health Department Crnotravska 17 11040 Belgrade Serbia
References provided by Crossref.org
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- $a Jaćević, Vesna $u Department for Experimental Toxicology and Pharmacology, National Poison Control Centre, Military Medical Academy, Crnotravska 17, 11040, Belgrade, Serbia; Medical Faculty of the Military Medical Academy, University of Defence, Crnotravska 17, 11040, Belgrade, Serbia. Electronic address: v_jacevic@yahoo.com
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- $a This study aimed to determine the paraoxonase activity and prooxidant-antioxidant balance in the brain tissue of Wistar rats following subacute treatment with selected K-oximes. Each K-oxime was administered intramuscularly (0.1 LD50/kg) twice per week for four weeks, and 7 days after the last treatment, the paraoxonase activity (PON1), the prooxidant-antioxidant balance (PAB), the levels of superoxide anion radical (O2•-), the concentration of nitrite (NO2-) and the content of free protein thiol groups in the brain homogenates were evaluated. The PON1 and PAB activity were significantly reduced in almost all oxime-treated groups (p < 0.01 and p < 0.001, respectively). The concentrations of O2•- were significantly increased in the obidoxime-, K048-, K074- and K075-treated groups (p < 0.001), while the levels of NO2- was significantly decreased in asoxime-, obidoxime-, K074 and K075-treated rats (p < 0.01, p < 0.001, respectively). The content of Thiol groups was significantly elevated in all oxime-treated groups (p < 0.001). Continuing our previously published data, these results confirmed that applied K-oximes improved the oxidative status and further harmful systemic effects of rats after subacute administration.
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