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Mother-child exposure to polychlorinated biphenyls and organochlorine pesticides in the Northern Finland cohort (NUGEN)

S. Palaniswamy, S. Salah, P. Přibylová, P. Kukučka, L. Laatio, E. Sieppi, M. Kummu, A. Rautio, P. Myllynen, K. Abass

. 2025 ; 115 (-) : 104679. [pub] 20250323

Language English Country Netherlands

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc25016231

Limited knowledge exists on persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs), in mother-child pairs from Northern Finland. This study examines plasma PCB and OCP concentrations and their determinants. Blood plasma concentrations of 13 PCBs and 6 OCPs were measured in mothers and in cord samples from the NUGEN birth cohort (N = 102, 2012-2014). Correlations between maternal and cord POPs were assessed using Spearman correlation, and linear regression identified factors influencing lipid-adjusted POPs. Maternal age and alcohol consumption during pregnancy were positively associated with PCBs and OCPs. Pre-pregnancy BMI and weight change during pregnancy were inversely associated with PCBs, but positively with p,p'-DDE in children. Increasing parity and smoking were associated with lower PCBs. Maternal fish consumption was associated with higher PCBs in children. Finnish pregnant women had lower PCBs and OCPs than other European populations. These findings inform exposure risk assessment and prevention strategies.

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$a Limited knowledge exists on persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs), in mother-child pairs from Northern Finland. This study examines plasma PCB and OCP concentrations and their determinants. Blood plasma concentrations of 13 PCBs and 6 OCPs were measured in mothers and in cord samples from the NUGEN birth cohort (N = 102, 2012-2014). Correlations between maternal and cord POPs were assessed using Spearman correlation, and linear regression identified factors influencing lipid-adjusted POPs. Maternal age and alcohol consumption during pregnancy were positively associated with PCBs and OCPs. Pre-pregnancy BMI and weight change during pregnancy were inversely associated with PCBs, but positively with p,p'-DDE in children. Increasing parity and smoking were associated with lower PCBs. Maternal fish consumption was associated with higher PCBs in children. Finnish pregnant women had lower PCBs and OCPs than other European populations. These findings inform exposure risk assessment and prevention strategies.
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$a Salah, Soha $u Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland
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$a Přibylová, Petra $u Masaryk University, Faculty of Science, RECETOX, Brno, Czech Republic
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$a Kukučka, Petr $u Masaryk University, Faculty of Science, RECETOX, Brno, Czech Republic
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$a Laatio, Liisa $u Research unit of Clinical Medicine, University of Oulu, Oulu, Finland
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$a Sieppi, Elina $u Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland
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$a Kummu, Maria $u Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland
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$a Rautio, Arja $u Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland; Arctic Health, Faculty of Medicine, University of Oulu, Oulu, Finland
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$a Myllynen, Päivi $u Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland; Northern Finland Laboratory Center Nordlab, Oulu, Finland
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$a Abass, Khaled $u Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland; Department of Environmental Health Sciences, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates; Sharjah Institute for Medical Research (SIMR), University of Sharjah, Sharjah, United Arab Emirates; Research Institute of Science and Engineering, University of Sharjah, Sharjah, United Arab Emirates. Electronic address: khaled.megahed@oulu.fi
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