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Continuous-flow synthesis of alpha-gliadin peptides in an ultrasonic field and assay of their inhibition of intestinal sucrase activity
J. Vagner, P. Kocna, V. Krchnak
Jazyk angličtina Země Spojené státy americké
Grantová podpora
IZ707
MZ0
CEP - Centrální evidence projektů
PubMed
1839365
Knihovny.cz E-zdroje
- MeSH
- duodenum enzymologie účinky léků MeSH
- gliadin farmakologie chemicky indukované chemie MeSH
- kuřecí embryo MeSH
- onkogenní proteiny virové chemie MeSH
- peptidové fragmenty farmakologie chemicky indukované chemie MeSH
- techniky in vitro MeSH
- ultrazvuk MeSH
- zvířata MeSH
- Check Tag
- kuřecí embryo MeSH
- zvířata MeSH
Three dodecapeptide amides derived from the amino acid sequence of alpha-gliadin and four of their analogues were synthesized by continuous-flow solid-phase multiple peptide synthesis. Ultrasonic field conditions accelerated the coupling reaction without affecting purity. Biological tests of the synthetic fragments showed the relevance of toxicity prediction for preselection of immunogenic alpha-gliadin fragments.
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- $a Research Institute for Feed Supplements and Veterinary Drugs Prague, CZ
- 520 9_
- $a Three dodecapeptide amides derived from the amino acid sequence of alpha-gliadin and four of their analogues were synthesized by continuous-flow solid-phase multiple peptide synthesis. Ultrasonic field conditions accelerated the coupling reaction without affecting purity. Biological tests of the synthetic fragments showed the relevance of toxicity prediction for preselection of immunogenic alpha-gliadin fragments.
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