Results of phenylalanine tolerance tests and EEG examination in patients under treatment for phenylketonuria
Jazyk angličtina Země Česko Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
615445
Knihovny.cz E-zdroje
- MeSH
- diferenciální diagnóza MeSH
- dítě MeSH
- dospělí MeSH
- elektroencefalografie MeSH
- fenylalanin * MeSH
- fenylketonurie diagnóza genetika MeSH
- heterozygot MeSH
- lidé MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- fenylalanin * MeSH
The EEG of 10 phenylketonuric children treated by a diet and of 4 children with hyperphenylalaninaemia on a normal diet was recorded during L-phenylalanine tolerance tests. The first recording was made before administering the L-phenylalanine load (100 mg/kg b.w.) and the second 60-120 min after. In 6 of the phenylketonuric children, nonspecific abnormality became more pronounced or increased, or previously absent epileptic graphoelements appeared. A pathological EEG response to a L-phenylalanine load was found in 1 child with hyperphenylalaninaemia. The authors do not recommend relaxation of the diet in children with a pathological EEG response to a L-phenylalanine load.