JavaScript is NOT enabled !

Please enable JavaScript.

Article

PubMed

This record comes from PubMed

Strain improvement in Streptomyces galilaeus, a producer of anthracycline antibiotics galirubins

Folia microbiologica. 1977 ; 22 (5) : 321-8.

Folia Microbiol (Praha)
ISSN 0015-5632
Source

Language English Country United States Media print

Document type Journal Article

Persistent link https://www.medvik.cz/link/pmid00924274

PubMed 924274
DOI 10.1007/bf02877666
Knihovny.cz E-resources

MeSH
Anthraquinones biosynthesis MeSH
Glycosides biosynthesis MeSH
Nitrous Acid pharmacology MeSH
Mutation drug effects radiation effects MeSH
Antibiotics, Antineoplastic biosynthesis MeSH
Streptomyces drug effects genetics metabolism radiation effects MeSH
Ultraviolet Rays MeSH
Gamma Rays MeSH
Publication type
Journal Article MeSH
Names of Substances
Anthraquinones MeSH
Glycosides MeSH
Nitrous Acid MeSH
Antibiotics, Antineoplastic MeSH

The production of epsilon-pyrromycinone glycosides in Streptomyces galilaeus increased 12-fold, with respect to the wild strain, as a result of a sequential procedure including both natural selection and treatment with mutagens (nitrous acid, UV light and gamma-irradiation). Nitrous acid exhibited the highest mutagenic effect, both in increasing the productivity and in inducing blocked mutants. A mutant strain blocked in the biosynthesis of glycosides and accumulating free epsilon-pyrromycinone as the principal metabolite was obtained.

See more in PubMed

Chem Ber. 1967;100(8):2561-8 PubMed

Ann N Y Acad Sci. 1954 Oct 29;60(1):155-67 PubMed

Z Allg Mikrobiol. 1977;17(1):47-50 PubMed

Ann N Y Acad Sci. 1974 May 10;235(0):601-12 PubMed

Folia Microbiol (Praha). 1974;19(2):133-8 PubMed

Antibiotiki. 1975;20(12):1061-5 PubMed

Folia Microbiol (Praha). 1971;16(3):197-204 PubMed

Z Allg Mikrobiol. 1975;15(5):383-5 PubMed

Folia Microbiol (Praha). 1977;22(3):182-8 PubMed

Ann N Y Acad Sci. 1959 Sep 30;81:914-49 PubMed

Folia Microbiol (Praha). 1977;22(2):139-59 PubMed