Vplyv kalciových antagonistov na celkový obsah vápnika a horcíka v aorte králikov po podávaní cholesterolovej diéty
[The effect of calcium antagonists on total calcium and magnesium levels in the aorta of rabbits after administration of dietary cholesterol]
Language Slovak Country Czech Republic Media print
Document type English Abstract, Journal Article
PubMed
1581945
- MeSH
- Aorta chemistry MeSH
- Arteriosclerosis metabolism MeSH
- Calcium Channel Blockers pharmacology MeSH
- Cholesterol, Dietary administration & dosage MeSH
- Magnesium analysis MeSH
- Rabbits MeSH
- Calcium analysis MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Male MeSH
- Animals MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Names of Substances
- Calcium Channel Blockers MeSH
- Cholesterol, Dietary MeSH
- Magnesium MeSH
- Calcium MeSH
The objective of the work was to investigate the effect of calcium blockers--dilthiazem (2 mg.kg-1.day-1), isradipine (2.5 mg.kg-1.day-1) and verapamil (0.25 mg.kg-1.day-1) on the calcium and magnesium content of the rabbit aorta with experimental atherosclerosis induced by a 1% cholesterol diet. In the aorta of rabbits kept on a cholesterol diet the calcium and magnesium content, as compared with a control group on a ordinary diet, increased significantly. In the experimental groups to whom during the eight-week period on the cholesterol diet at regular 12-hour intervals calcium antagonists were administered the calcium and magnesium content of the aorta reached normal levels. The antiatherogenic effect was, however, produced only by verapamil when administered in therapeutic doses.
