Quantitative aspects of the fever response elicited by intracerebral injection of endotoxin in the guinea-pig
Physiological research.
1992 ;
41 (1) :
63-4.
Language English Country Czech Republic Media print
Document type Journal Article
Persistent link
https://www.medvik.cz/link/pmid01610780
PubMed
1610780
Knihovny.cz E-resources
- MeSH
- Analysis of Variance MeSH
- Preoptic Area MeSH
- Endotoxins administration & dosage pharmacology MeSH
- Fever chemically induced physiopathology MeSH
- Indomethacin pharmacology MeSH
- Injections MeSH
- Lipopolysaccharides administration & dosage MeSH
- Guinea Pigs MeSH
- Animals MeSH
- Check Tag
- Guinea Pigs MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Endotoxins MeSH
- Indomethacin MeSH
- Lipopolysaccharides MeSH
Fever developing after intracerebral injections of lipopolysaccharide (LPS) to guinea-pigs were monophasic, with only one peak of inner body temperature slowly developing and longlasting in a dose range 20 to 200 ng of LPS. Latency time was inversely related to the dose of LPS. Indomethacin injected to the third brain ventricle did not abolish fever response.
