The effect of beta-adrenoceptor blocking drugs on histamine liberation, prostaglandin synthesis and phospholipid turnover in isolated mast cells stimulated with concanavalin A
Jazyk angličtina Země Švýcarsko Médium print
Typ dokumentu časopisecké články
PubMed
1695467
DOI
10.1007/bf01969003
Knihovny.cz E-zdroje
- MeSH
- beta blokátory farmakologie MeSH
- fosfatidylseriny farmakologie MeSH
- fosfolipidy metabolismus MeSH
- konkanavalin A farmakologie MeSH
- krysa rodu Rattus MeSH
- kyselina arachidonová MeSH
- kyseliny arachidonové metabolismus MeSH
- mastocyty účinky léků metabolismus MeSH
- membránové lipidy metabolismus MeSH
- prostaglandiny biosyntéza MeSH
- radioizotopy fosforu MeSH
- radioizotopy vápníku MeSH
- techniky in vitro MeSH
- thromboxan B2 biosyntéza MeSH
- uvolňování histaminu účinky léků MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- beta blokátory MeSH
- fosfatidylseriny MeSH
- fosfolipidy MeSH
- konkanavalin A MeSH
- kyselina arachidonová MeSH
- kyseliny arachidonové MeSH
- membránové lipidy MeSH
- prostaglandiny MeSH
- radioizotopy fosforu MeSH
- radioizotopy vápníku MeSH
- thromboxan B2 MeSH
Exaprolol, metipranolol and propranolol decreased significantly histamine liberation, degranulation, 45Ca uptake and thromboxane B2 formation in isolated rat mast cells stimulated with concanavalin A and phosphatidylserine. Moreover, exaprolol and metipranolol decreased 32P incorporation into membrane phospholipids and metipranolol and propranolol reduced the liberation of arachidonic acid from membrane phospholipids of stimulated mast cells. Exaprolol significantly increased the arachidonic acid liberation from these cells. Possible mechanisms of interaction of beta-adrenoceptor blocking drugs with isolated mast cells are discussed.
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