Effect of chloroquine on isolated mast cells
Language English Country Switzerland Media print
Document type Journal Article
PubMed
1716835
DOI
10.1007/bf01993121
Knihovny.cz E-resources
- MeSH
- Adrenergic beta-Antagonists MeSH
- Calcimycin pharmacology MeSH
- Chloroquine administration & dosage pharmacology MeSH
- Phosphatidylserines pharmacology MeSH
- Rats, Inbred Strains MeSH
- Concanavalin A pharmacology MeSH
- Rats MeSH
- Mast Cells drug effects physiology MeSH
- p-Methoxy-N-methylphenethylamine pharmacology MeSH
- Propanolamines pharmacology MeSH
- Thromboxane B2 biosynthesis MeSH
- Histamine Release drug effects MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Adrenergic beta-Antagonists MeSH
- Calcimycin MeSH
- Chloroquine MeSH
- exaprolol MeSH Browser
- Phosphatidylserines MeSH
- Concanavalin A MeSH
- p-Methoxy-N-methylphenethylamine MeSH
- Propanolamines MeSH
- Thromboxane B2 MeSH
Chloroquine liberated a relatively low amount of histamine from isolated rat mast cells. In a dose-dependent way, this drug inhibited histamine liberation from mast cells stimulated with compound 48/80, A23187, concanavalin A plus phosphatidylserine (Con A + PS) and abolished histamine liberation induced by exaprolol. The degranulation was decreased in cells stimulated with 48/80, Con A + PS and exaprolol. Chloroquine significantly inhibited the formation of thromboxane B2 in mast cells stimulated with 48/80, Con A + PS and A23187. We assume that chloroquine interferes with mast cells at a plasmic membrane site as well as intracellularly.
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