Vergleich einiger pharmakokinetischer Parameter der in der Veterinärmedizin am häufigsten angewandten Tetrazykline
[Comparison of pharmacokinetic parameters of tetracyclines which are most frequently used in veterinary medicine]
Language German Country Germany Media print
Document type English Abstract, Journal Article
PubMed
1789718
Knihovny.cz E-resources
- MeSH
- Administration, Oral MeSH
- Chlortetracycline administration & dosage pharmacokinetics MeSH
- Rabbits metabolism MeSH
- Oxytetracycline administration & dosage pharmacokinetics MeSH
- Half-Life MeSH
- Tetracycline administration & dosage pharmacokinetics MeSH
- Animals MeSH
- Check Tag
- Rabbits metabolism MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Names of Substances
- Chlortetracycline MeSH
- Oxytetracycline MeSH
- Tetracycline MeSH
40 adult White Californian rabbits were monitored for serum levels, soft tissue concentrations, and biological half-life of technical chlorotetracycline (Aureovit 12 C40 -- SPOFA), chlorotetracycline chloride (Farmitalia substance), tetracycline chloride (tetramyocine tablets for veterinary use -- SPOFA), and oxytetracycline chloride (oxymycoine in powder form for solution for veterinary use -- SPOFA), following application of 20 micrograms.kg-1. All tetracyclines tested were orally administered by gavage, following dissolution or suspension (Aureovit 12 C40). Statistically significant differences were found to exist among serum levels of various tetracyclines, with the 1st to 11th hours from administration, whereafter differences turned minimal between the 11th and 24th hours. Differences were found to exist also among concentrations in various organs.
