Melatonin inhibitory effect on luteinizing hormone release is potentiated after long pretreatment with the indole
Language English Country Netherlands Media print
Document type Journal Article
PubMed
1849438
DOI
10.1016/0006-8993(91)90449-6
PII: 0006-8993(91)90449-6
Knihovny.cz E-resources
- MeSH
- Cyclic AMP metabolism MeSH
- Gonadotropin-Releasing Hormone pharmacology MeSH
- Pituitary Gland drug effects metabolism MeSH
- Rats, Inbred Strains MeSH
- Indoles pharmacology MeSH
- Colforsin pharmacology MeSH
- Rats MeSH
- Luteinizing Hormone metabolism MeSH
- Melatonin pharmacology MeSH
- Animals, Newborn metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cyclic AMP MeSH
- Gonadotropin-Releasing Hormone MeSH
- Indoles MeSH
- Colforsin MeSH
- Luteinizing Hormone MeSH
- Melatonin MeSH
The effect of melatonin on luteinizing-hormone releasing-hormone stimulation of cyclic AMP accumulation and luteinizing hormone (LH) release from neonatal rat hemipituitaries was studied in vitro. Melatonin inhibited LH-release from pituitaries of animals kept previously on long but not on short photoperiods; cyclic AMP accumulation was, however, inhibited on both photoperiods. There were no daily changes in the melatonin effect. Inhibition of LH-release was strongly potentiated after 6 h preincubation with melatonin as compared with 20 min preincubation; cyclic AMP was not significantly affected by the length of preincubation.
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