Combined radioprotection by preirradiation peroral cystamine and postirradiation glucan administration
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
1908392
Knihovny.cz E-resources
- MeSH
- beta-Glucosidase pharmacology MeSH
- Whole-Body Irradiation MeSH
- Cystamine administration & dosage pharmacology MeSH
- Femur MeSH
- Glucan 1,3-beta-Glucosidase MeSH
- Hematopoietic Stem Cells drug effects radiation effects MeSH
- Hematopoiesis drug effects radiation effects MeSH
- Bone Marrow drug effects radiation effects MeSH
- Drug Interactions MeSH
- Mice MeSH
- Radiation-Protective Agents pharmacology MeSH
- Spleen drug effects radiation effects MeSH
- Radiation Tolerance MeSH
- Gamma Rays MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- beta-Glucosidase MeSH
- Cystamine MeSH
- Glucan 1,3-beta-Glucosidase MeSH
- Radiation-Protective Agents MeSH
The possibilities of combined radioprotection, using preirradiation peroral cystamine and postirradiation intraperitoneal glucan administration in sublethally and lethally whole-body gamma-irradiated mice were investigated. The results demonstrated at least additive radioprotective effects of both agents, manifested in the enhancement of postirradiation haemopoietic recovery and increased survival of irradiated mice. The effects appear to depend on the sequential cell protection mediated by cystamine and enhanced haemopoietic repopulation induced by glucan.
Effects of glucan on bone marrow
Modulation of animal and human hematopoiesis by β-glucans: a review
