Toxické poskození zrakových nervů pri lécbĕ ethambutolem u chronicky dialyzovaného pacienta
[Toxic damage of the optic nerve in treatment with ethambutol in a patient on chronic dialysis]
Language Czech Country Czech Republic Media print
Document type Case Reports, English Abstract, Journal Article
PubMed
1913897
- MeSH
- Kidney Failure, Chronic therapy MeSH
- Renal Dialysis * MeSH
- Ethambutol adverse effects pharmacokinetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Tuberculosis, Spinal drug therapy MeSH
- Optic Neuritis chemically induced MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- Ethambutol MeSH
The authors give an account of a 57-year-old male patient who was regularly dialyzed for two years and treated because of suspect TB of the spine with antituberculotics, incl. ethambutol. In the course of 8-9 months he was given 17.9 mg/kg ethambutol per day. Because of the practically zero excretion by the damaged kidney the drug cumulated in the serum and reached toxic levels before dialysis. Gradual deterioration of eyesight developed (central acuity and colour sense) which resulted in bilateral atrophy of the optic nerves with concentric narrowing of the visual field.
