Some electrochemical characteristics of synthetic analogs of nucleic acid components. III. Derivatives of 5-fluorouridine. An attempt to find correlation between some of their characteristics
Jazyk angličtina Země Slovensko Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
2041581
Knihovny.cz E-zdroje
- MeSH
- ftorafur chemie farmakologie MeSH
- kyselina lipoová MeSH
- leukemie L1210 MeSH
- nádorové buňky kultivované účinky léků MeSH
- nukleové kyseliny chemická syntéza MeSH
- polarografie MeSH
- uracilnukleotidy chemie MeSH
- uridin analogy a deriváty chemická syntéza farmakologie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- 5-fluorouridine MeSH Prohlížeč
- ftorafur MeSH
- kyselina lipoová MeSH
- nukleové kyseliny MeSH
- uracilnukleotidy MeSH
- uridin MeSH
The polarographic reduction and parameter tg alpha of a series of synthetic 5-fluorouracil derivatives (various 5'-modified nucleosides) were studied. The studied compounds were compared with analogous nucleosides of the uridine series. It was confirmed that the value of tg alpha which may suggest a potential carcinogenic activity of the compound studied, is dependent upon the reducibility of the compound and is associated with the cleavability of the nucleoside bond, i.e. with the ability to liberate fluorouracil. It was found that Ftorafur, an antitumor agent widely used in clinical practice, displayed a very high value of tg alpha. In the group of polyaromates such high tg alpha values had been found in compounds which are known to have carcinogenic activity.
