Vliv terguridu na kontraktilitu krysího dĕlozního prouzku
[The effect of terguride on contractility of rat uterine strips]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article
PubMed
2102577
- MeSH
- Uterine Contraction drug effects MeSH
- Rats, Inbred Strains MeSH
- Rats MeSH
- Lisuride analogs & derivatives pharmacology MeSH
- In Vitro Techniques MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Female MeSH
- Animals MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Names of Substances
- dironyl MeSH Browser
- Lisuride MeSH
The effects of terguride on the uterotonic activity of rat's uterine stria were investigated by means of a standardized isometric method of measuring in vitro the contractility of uterine muscles. The uterotonic activity of the given preparation depends on its concentration and on the phase of uterine cycle. The uterotonic activity makes 71.4 U.mg-1 in the range of terguride concentrations from 10(-7) to 10(-5) mg per ml. Used at higher concentrations, the uterotonic activity of terguride is very low. Spontaneous contractions are moderated and the tone of uterus is decreased by terguride administration.
