IgG1-4 subclasses in paraproteinemias
Language English Country Slovakia Media print
Document type Journal Article
PubMed
2320182
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Immunoglobulin A analysis MeSH
- Immunoglobulin G analysis classification MeSH
- Middle Aged MeSH
- Humans MeSH
- Paraproteinemias immunology MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Immunoglobulin A MeSH
- Immunoglobulin G MeSH
The concentration of IgG1-4 subclasses was determined in a series of 10 IgG1 paraproteinemias (5 multiple myelomas and 5 non-myeloma paraproteinemias) and in a series of 11 IgA paraproteinemias (7 multiple myelomas and 4 non-myeloma paraproteinemias). In the group of IgG1 myelomas, deficiency was established in the subclasses IgG2-4, in the group of IgA myelomas, deficiency was proved in all IgG1-4 subclasses as compared with non-myeloma paraproteinemias. Decreased IgG heterogeneity in IgG1 myelomas was demonstrated by the method of isoelectric focusing.
