Chlorinated phenols as metabolites of lindane. Evaluation of the degree of conjugation in rat urine
Language English Country England, Great Britain Media print
Document type Journal Article
PubMed
2468825
DOI
10.1093/jat/13.1.27
Knihovny.cz E-resources
- MeSH
- Administration, Oral MeSH
- Time Factors MeSH
- Chlorophenols metabolism urine MeSH
- Chromatography, Gas methods MeSH
- Electrochemistry MeSH
- Hexachlorocyclohexane administration & dosage metabolism MeSH
- Rats, Inbred Strains MeSH
- Rats MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Chlorophenols MeSH
- Hexachlorocyclohexane MeSH
After lindane was administered to rats in a single oral dose, the time profile of the degree of conjugation of the main phenolic metabolites was evaluated. In all urine samples 2,3-dichlorophenol, 2,4,5- and 2,4,6-trichlorophenol, and 2,3,5,6-tetrachlorophenol were constantly present. 2,3,5,6-Tetrachlorophenol and then 2,4,6-trichlorophenol were the prevalent metabolites in all cases. The degree of conjugation did not correlate with the dissociation constant of individual chlorinated phenols. Phenol conjugation declined with time after administration.
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