Effects of mescaline and its derivative N-[3,4,5-trimethoxyphenylethyl]-aziridine on the spatial orientation of rats in a T-maze
Language English Country Czech Republic Media print
Document type Comparative Study, Journal Article
PubMed
2534189
Knihovny.cz E-resources
- MeSH
- Aziridines administration & dosage pharmacology MeSH
- Behavior, Animal drug effects MeSH
- Rats, Inbred Strains MeSH
- Injections, Intraventricular MeSH
- Rats MeSH
- Mescaline administration & dosage analogs & derivatives pharmacology MeSH
- Orientation drug effects MeSH
- Memory drug effects MeSH
- Spatial Behavior * MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Aziridines MeSH
- Mescaline MeSH
The central effect of mescaline and of its derivative N-[3,4,5- trimethoxyphenylethyl]-aziridine (FAZ) after their stereotaxic administration into the lateral ventricle of the brain was studied in behavioural experiments on rats. The effect of the two substances was tested by a method studying memory elicitation in response to appetitive motivation in a multiple T-maze. The results show that both substances worsened the behaviour in question. The negative effect of mescaline (lengthening of the time of passage through the maze) was manifested both immediately and several weeks after a single dose. FAZ likewise worsened the test reaction, but its effect was less pronounced than that of mescaline.
