Inhibition of phosphatase by open-chain nucleoside analogues in insects
Language English Country Switzerland Media print
Document type Journal Article
PubMed
2537747
DOI
10.1007/bf01954853
Knihovny.cz E-resources
- MeSH
- Adenine analogs & derivatives pharmacology MeSH
- Alkaline Phosphatase antagonists & inhibitors MeSH
- Phosphoric Monoester Hydrolases antagonists & inhibitors MeSH
- Hemiptera enzymology MeSH
- Acid Phosphatase antagonists & inhibitors MeSH
- Malpighian Tubules enzymology MeSH
- Nitrophenols metabolism MeSH
- Organophosphorus Compounds metabolism MeSH
- Intestines enzymology MeSH
- Animals MeSH
- Check Tag
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- 9-(2,3-dihydroxypropyl)adenine MeSH Browser
- Adenine MeSH
- Alkaline Phosphatase MeSH
- eritadenine MeSH Browser
- Phosphoric Monoester Hydrolases MeSH
- Acid Phosphatase MeSH
- Nitrophenols MeSH
- nitrophenylphosphate MeSH Browser
- Organophosphorus Compounds MeSH
(S)-9-(2,3-dihydroxypropyl) adenine (DHPA), D-eritadenine and some other open-chain nucleoside analogues, which exhibit adverse biological effects in microorganisms, plants and animals, cause pronounced inhibition of intestinal phosphatases in the hemipteran insect Pyrrhocoris apterus. The rate of p-nitrophenylphosphate hydrolysis by homogenates from intestinal epithelium and Malpighian tubules was inhibited up to 94% by 2-10 millimolar concentrations of these drugs. This effect is stronger than that of sodium fluoride, which is recognized as a common inhibitor of phosphatase. We conclude that inhibition of phosphatase activity in the digestive and excretory organs may be responsible for the previously reported massive excretion of phosphorylated derivatives of the nucleoside analogues after their oral administration to insects.
