Inhibition of phosphatase by open-chain nucleoside analogues in insects
Jazyk angličtina Země Švýcarsko Médium print
Typ dokumentu časopisecké články
PubMed
2537747
DOI
10.1007/bf01954853
Knihovny.cz E-zdroje
- MeSH
- adenin analogy a deriváty farmakologie MeSH
- alkalická fosfatasa antagonisté a inhibitory MeSH
- fosfatasy antagonisté a inhibitory MeSH
- Hemiptera enzymologie MeSH
- kyselá fosfatasa antagonisté a inhibitory MeSH
- malpighické trubice enzymologie MeSH
- nitrofenoly metabolismus MeSH
- organofosforové sloučeniny metabolismus MeSH
- střeva enzymologie MeSH
- zvířata MeSH
- Check Tag
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- 9-(2,3-dihydroxypropyl)adenine MeSH Prohlížeč
- adenin MeSH
- alkalická fosfatasa MeSH
- eritadenine MeSH Prohlížeč
- fosfatasy MeSH
- kyselá fosfatasa MeSH
- nitrofenoly MeSH
- nitrophenylphosphate MeSH Prohlížeč
- organofosforové sloučeniny MeSH
(S)-9-(2,3-dihydroxypropyl) adenine (DHPA), D-eritadenine and some other open-chain nucleoside analogues, which exhibit adverse biological effects in microorganisms, plants and animals, cause pronounced inhibition of intestinal phosphatases in the hemipteran insect Pyrrhocoris apterus. The rate of p-nitrophenylphosphate hydrolysis by homogenates from intestinal epithelium and Malpighian tubules was inhibited up to 94% by 2-10 millimolar concentrations of these drugs. This effect is stronger than that of sodium fluoride, which is recognized as a common inhibitor of phosphatase. We conclude that inhibition of phosphatase activity in the digestive and excretory organs may be responsible for the previously reported massive excretion of phosphorylated derivatives of the nucleoside analogues after their oral administration to insects.
