The adhesin structures involved in the adherence of group B streptococci to human vaginal cells
Language English Country United States Media print
Document type Journal Article
PubMed
3098655
DOI
10.1007/bf02936605
Knihovny.cz E-resources
- MeSH
- Bacterial Adhesion * drug effects radiation effects MeSH
- Glutaral pharmacology MeSH
- Humans MeSH
- Neuraminidase pharmacology MeSH
- Pepsin A pharmacology MeSH
- Streptococcus agalactiae pathogenicity MeSH
- Trypsin pharmacology MeSH
- Ultraviolet Rays MeSH
- Vagina microbiology MeSH
- Hot Temperature MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Glutaral MeSH
- Neuraminidase MeSH
- Pepsin A MeSH
- Trypsin MeSH
The adherence of group B streptococci (GBS) of serotypes Ia, II and III to human vaginal cells was studied in vitro. The adherence was not dependent on the viability of bacteria; killing of GBS by UV irradiation or glutaraldehyde treatment did not inhibit the adherence. Killing of GBS by heating to 56 degrees C for 1 h led to a pronounced decrease of adherence, demonstrating the thermosensitivity of the GBS structures involved. The protein nature of these structures was proved by a significant reduction of adherence after pretreatment of GBS with trypsin or pepsin. Pretreatment of GBS with sialidase had no influence on the adherence. Such a pretreatment of vaginal cells caused an increase of adherence showing that the receptors on epithelial cells may be partly masked by sialic acid.
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