Renal function in brain dead patients with respect to transplantation
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
6219407
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Potassium metabolism MeSH
- Creatinine metabolism MeSH
- Kidney metabolism MeSH
- Humans MeSH
- Adolescent MeSH
- Urea metabolism MeSH
- Brain Death * MeSH
- Nephrectomy * MeSH
- Osmolar Concentration MeSH
- Child, Preschool MeSH
- Sodium metabolism MeSH
- Kidney Transplantation * MeSH
- Kidney Function Tests * MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Potassium MeSH
- Creatinine MeSH
- Urea MeSH
- Sodium MeSH
We examined the renal function in 18 brain dead patients 2-0 h before removing the kidneys and 72 h after their transplantation to the recipient. The kidneys were preserved by simple hypothermia. In brain dead patients we found no demonstrable relationships between PCr and CCr or between Purea and CCr. At this time the Purea and PCr values are not a sufficiently accurate indicator of renal function. We also examined the plasma and urinary concentrations of Na, K, urea and osmotically active substances and calculated their excretion fractions. We found that, prior to removal, the kidneys were in a state of combined osmotic and water diuresis. The osmotic diuresis was chiefly of a non-sodium type and was produced by a mannitol load. Water diuresis was evidently caused by inhibition of ADH output consequent to brain hypoxia. We also investigated the relationship between the CCr values before nephrectomy and in the early posttransplantation phase. We found that there was a relationship between the recipient's CCr values in the early posttransplantation period and donor's CCr/total ischaemic time index. Calculation of this index can be valuable, especially in high risk transplantations.