Phagocytic capacity of human leukocytes preincubated with Imuran and prednisone
Jazyk angličtina Země Česko Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
6358349
Knihovny.cz E-zdroje
- MeSH
- azathioprin farmakologie MeSH
- bakteriální infekce imunologie MeSH
- baktericidní aktivita krve účinky léků MeSH
- buněčná imunita účinky léků MeSH
- Candida albicans imunologie MeSH
- fagocytóza účinky léků MeSH
- imunologická tolerance účinky léků MeSH
- imunosupresiva farmakologie MeSH
- lidé MeSH
- neutrofily účinky léků imunologie MeSH
- prednison farmakologie MeSH
- recidiva MeSH
- techniky in vitro MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- azathioprin MeSH
- imunosupresiva MeSH
- prednison MeSH
The phagocytic and microbicidal activities of human polymorphonuclear leukocytes (PMNL) were tested after a short-term preincubation of phagocytic cells with Imuran or Prednisone, using C. albicans strains as a test organism. The tests showed that both immunosuppressive agents reduced significantly the microbicidal activity of PMNL cells by 35-40%. Detectable differences in the phagocytic activity and phagocytic index values were not statistically significant. The decreased ability of PMNLs to kill ingested C. albicans strains appears thus to sensitively reflect the altered PMNL function and can be utilized in the biologic monitoring of immunosuppression. The reduced microbicidal potential of phagocytic cells may be also one of the causes of recurrent microbial infections that are so frequent in immunosuppressant-treated patients.
