Immunosuppressive effects of a synthetic polymer poly N-(2-hydroxypropyl)methacrylamide (Duxon)
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
6449390
Knihovny.cz E-resources
- MeSH
- Cell Division drug effects MeSH
- Cell Line MeSH
- Transplantation, Homologous MeSH
- Rats MeSH
- Cells, Cultured MeSH
- Polymethacrylic Acids pharmacology MeSH
- Lymphocytes drug effects immunology MeSH
- Mice MeSH
- Plasma Substitutes pharmacology MeSH
- Graft Survival drug effects MeSH
- Lymphocyte Culture Test, Mixed MeSH
- Skin Transplantation MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Duxon MeSH Browser
- Polymethacrylic Acids MeSH
- Plasma Substitutes MeSH
Poly N-(2-hydroxypropyl)methacrylamide (Duxon) was studied as a substitute of blood plasma and was found to prolong significantly the survival of semiallogeneic skin grafts in mice and rats and to reduce MLC reactions of human lymphocytes. It did not inhibit the growth of lymphocytes and the growth of the fibroblast-like (diploid) or epithelioid (heteroploid) cell lines in tissue culture.
HPMA Copolymer-Based Nanomedicines in Controlled Drug Delivery
