Bar-pressing for water reward: effects of nootropic drugs and peptides on discrimination learning in rats
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
6475474
Knihovny.cz E-resources
- MeSH
- Discrimination Learning drug effects MeSH
- Imidazolidines * MeSH
- Imidazoles pharmacology MeSH
- Rats, Inbred Strains MeSH
- Rats MeSH
- Lypressin analogs & derivatives pharmacology MeSH
- Reward MeSH
- Conditioning, Operant drug effects MeSH
- Peptides pharmacology MeSH
- Piracetam pharmacology MeSH
- Pyrrolidinones pharmacology MeSH
- Water MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- 2-oxoimidazolidine-1-carboxylic acid-leucyl-beta-alaninamide MeSH Browser
- Imidazolidines * MeSH
- Imidazoles MeSH
- Lypressin MeSH
- Peptides MeSH
- Piracetam MeSH
- Pyrrolidinones MeSH
- vasopressin, N-alpha-Gly-Gly-Gly-8-Lys-9-des-GlyNH2- MeSH Browser
- Water MeSH
- VUFB 13763 MeSH Browser
Rats maintained on 23-hr water deprivation were first trained to bar-press for continuous water reinforcement and then to discriminate between regularly alternating periods (24 sec) during which time a light signal was either on and each response was reinforced or the light was off and bar-presses were not rewarded. The following drugs were injected s. c. prior to the sessions of discriminative learning: piracetam, 1-(4-Methyl-piperazinocarbonylmethyl)-2-pyrrolidone/hydrogen maleate (VUFB 13763), N alpha-glycyl-glycyl[8-lysine]des-9-glycinamide-vasopressin (DG-Trigly-LVP) and an analog of MIF, EUC-Leu-beta-Ala-NH2 (EUC, 2-oxoimidazolidine-1-carboxylic acid). None of the drugs influenced the total number of bar-pressing (sum of reinforced and non reinforced responses). Piracetam (100 mg.kg-1), VUFB 13763 (40 mg.kg-1) and EUC-Leu-beta-Ala-NH2 (1 mg.kg-1) improved the performance of rats on the discrimination learning task, DG-Trigly-LVP slowed the rate of acquisition.
