The influence of tetrachloromethane on subcellular structures of rat hepatocyte lysosomal and cytoplasmic enzymes of the liver, lungs and blood serum of rats during continuous and intermittent action of tetrachloromethane
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
7190985
Knihovny.cz E-resources
- MeSH
- Fructose-Bisphosphate Aldolase metabolism MeSH
- Carbon Tetrachloride pharmacology MeSH
- Cytoplasm enzymology MeSH
- Hydrolases metabolism MeSH
- Liver enzymology ultrastructure MeSH
- Rats MeSH
- L-Lactate Dehydrogenase metabolism MeSH
- Lysosomes enzymology MeSH
- Lung enzymology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Fructose-Bisphosphate Aldolase MeSH
- Carbon Tetrachloride MeSH
- Hydrolases MeSH
- L-Lactate Dehydrogenase MeSH
The authors performed a comparative biochemical study of some enzymes of lysosomic origin (hyaluronidase, N-acetyl-beta-D-glucosaminidase, beta-glucosidase, beta-galatosidase and acid phosphatase), of the state of enzyme substrate system N-acetylneuraminic acid---aldolase of neuramic acid and of the activity of lactatedehydrogenase (soluble in cytosol and bound on mitochodria) in the liver, lungs and blood serum of rats at various regimens of the inhalation action of CCl4. On the basis of results obtained they determined the biological importance of the change of activity of enzymes differently localized in cells at the adaptation of an organisme to the noxious action of CCl4.
