The ability to measure insulin sensitivity plays important role mainly in investigation of pathogenesis of noninsulin-dependent diabetes mellitus. The measurement of insulin sensitivity means to measure the insulin's effect on glucose metabolism--on hepatic glucose production and peripheral glucose uptake. From all in vivo techniques for measurement of insulin sensitivity are considered for most suitable at the present time next 2: clamp technique (euglycemic hyperinsulinemic and hyperglycemic hyperinsulinemic clamp) and Bergman's minimal model technique. Clamp methods and minimal model method are significantly correlated in vivo methods for measurement of insulin sensitivity and beta-cell secretory function as well.

1 interná klinika metabolická jednotka Martinská fakultná nemocnica Martin