Monitorování gynekologických maligních nádorů imunitní odpovĕdí na LDH virový antigen
[Monitoring of malignant gynecologic tumors using the immune response to lactate dehydrogenase virus antigens]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article, Research Support, Non-U.S. Gov't
PubMed
7804568
- MeSH
- Antigens, Viral immunology MeSH
- Immunity, Cellular MeSH
- Lactate dehydrogenase-elevating virus immunology MeSH
- Humans MeSH
- Genital Neoplasms, Female diagnosis immunology MeSH
- Sensitivity and Specificity MeSH
- Leukocyte Adherence Inhibition Test * MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antigens, Viral MeSH
The cell mediated immunity was examined by the leukocyte adherence inhibition (LAI) test in 21 patients with CIN III and 146 patients with invasive gynaecologic malignancies before treatment and at 3-month intervals. Our own LDV antigen and organ specific antigens were used. The test was highly specific (95.1%) in comparison with a control group of healthy blood donors. The sensitivity of the test was lower (64.7-86.8%). There was no correlation with the development of disease (remission or relapse). The test in a two-year investigation does not seem suitable for monitoring of disease. Depending the nature of LDV infection, only a longer investigation extending over more years would enable further conclusions.
