Production of 26-deoxymonensins A and B by Streptomyces cinnamonensis in the presence of Metyrapone
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8017935
PubMed Central
PMC201517
DOI
10.1128/aem.60.5.1561-1564.1994
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents biosynthesis chemistry isolation & purification MeSH
- Mass Spectrometry MeSH
- Magnetic Resonance Spectroscopy MeSH
- Metyrapone analogs & derivatives metabolism MeSH
- Monensin analogs & derivatives biosynthesis chemistry isolation & purification MeSH
- Pyridines metabolism pharmacology MeSH
- Streptomyces drug effects metabolism MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 26-deoxymonensin A MeSH Browser
- 26-deoxymonensin B MeSH Browser
- Anti-Bacterial Agents MeSH
- metapyrone MeSH Browser
- metyrapol MeSH Browser
- Metyrapone MeSH
- Monensin MeSH
- Pyridines MeSH
Metyrapone, a potent cytochrome P-450 inhibitor, added at 9 mM to a submerged culture of Streptomyces cinnamonensis caused partial inhibition of total monensin biosynthesis and coproduction of new metabolites, 26-deoxymonensins A and B. The latter was isolated as its 25-O-methyl derivative. Metyrapone was simultaneously reduced to metyrapol. All of these compounds were identified by nuclear magnetic resonance spectroscopy and mass spectrometry.
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