Vliv antioxidacní látky butylhydroxyanizolu na oxidacní fosforylaci mitochondrií myokardu pri experimentálnĕ vyvolané ischemii
[The effect of butylhydroxyanisole, an antioxidant, on oxidative phosphorylation of myocardial mitochondria in experimental ischemia]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article
PubMed
8143327
- MeSH
- Antioxidants pharmacology MeSH
- Butylated Hydroxyanisole pharmacology MeSH
- Myocardial Ischemia metabolism MeSH
- Rats MeSH
- Oxidative Phosphorylation drug effects MeSH
- Rats, Wistar MeSH
- Mitochondria, Heart drug effects metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Names of Substances
- Antioxidants MeSH
- Butylated Hydroxyanisole MeSH
The present paper evaluated the effect of the antioxidatively acting agent butylhydroxyanisole (BHA) on the oxidative and energetic processes in the mitochondria of the myocardium, both normal and damaged with isoprenaline. BHA was administered for 20 days in a daily dose of 10 mg.kg-1. Experimental necrosis of the myocardium was induced by a single-dose administration of a dose of 25 mg.kg-1 s.c. The results shown in Graphs 1-7 indicate that BHA in the above-mentioned concentration did not act protectively on the metabolic processes taking place in the mitochondria during experimentally induced necroses of the myocardium.
