Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). I. Lymphatic leukemia KHP-Lw-I in Lewis rats
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8157134
Knihovny.cz E-resources
- MeSH
- Adenine analogs & derivatives therapeutic use MeSH
- Leukemia, Experimental drug therapy pathology MeSH
- Rats MeSH
- Leukemia, Lymphoid drug therapy pathology MeSH
- Organophosphonates * MeSH
- Rats, Inbred Lew MeSH
- Antineoplastic Agents therapeutic use MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- adefovir MeSH Browser
- Adenine MeSH
- Organophosphonates * MeSH
- Antineoplastic Agents MeSH
PMEA was administered i.p. daily on 10 consecutive days to inbred LEW rats inoculated with leukemic lymphoblastic cells KPH-Lw-I. The treatment was started 24 h after the inoculation. The observed cytostatic effects consisted in a significant prolongation of survival time associated with a suppression of the number of bone marrow leukemia cells with characteristic chromosomal marker of KPH-Lw-I leukemia as well as with a depression of the number of lymphoblasts in the blood.
