Utilizace glukózy a riziko hyperglykémie pri soucasném podávání vĕtvených aminokyselin a tukové emulze u zdravých osob
[Glucose utilization and risk of hyperglycemia during simultaneous administration of branched-chain amino acids and fat emulsions in healthy persons]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article
PubMed
8513466
- MeSH
- Adult MeSH
- Glucose Tolerance Test * MeSH
- Hyperglycemia etiology MeSH
- Infusions, Intravenous MeSH
- Blood Glucose metabolism MeSH
- Humans MeSH
- Risk Factors MeSH
- Fat Emulsions, Intravenous administration & dosage adverse effects MeSH
- Amino Acids, Branched-Chain administration & dosage adverse effects MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Names of Substances
- Blood Glucose MeSH
- Fat Emulsions, Intravenous MeSH
- Amino Acids, Branched-Chain MeSH
In order to evaluate the effect of substrate competition on glucose utilization, we studied 8 healthy volunteers under three different conditions: 1. Hyperinsulinemic (75 a 550 microU/ml) euglycemic (5 mmol/1) clamp (HEC). 2. HEC with Nutramin VLI infusion given at a rate of 2 ml/kg.h. 3. HEC with infusion of Nutramin VLI (2 ml/kg.h) and Intralipid (0.15 g of fat/kg.h). Glucose utilization was evaluated as the glucose disposal rate during HEC. We have found, that Nutramin VLI given alone or with Intralipid does not significantly decrease glucose utilization at insulinemia of about 75 and 550 microU/ml. We conclude that simultaneous administration of substrates during parenteral nutrition at standard rates does not raise the risk of hyperglycemia in healthy men.
