Changes of some biochemical and hematological parameters following administration of daunorubicin in rabbits
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
8584862
Knihovny.cz E-resources
- MeSH
- Blood Chemical Analysis MeSH
- Daunorubicin pharmacology MeSH
- Electrocardiography drug effects MeSH
- Rabbits MeSH
- Blood drug effects MeSH
- Blood Cell Count drug effects MeSH
- Antibiotics, Antineoplastic pharmacology MeSH
- Antineoplastic Agents pharmacology MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Daunorubicin MeSH
- Antibiotics, Antineoplastic MeSH
- Antineoplastic Agents MeSH
The effects of the repeated i.v. administration of daunorubicin (50 mg/m2, once weekly, max. 9 weeks) were investigated in rabbits in vivo to analyze biochemical and hematological changes. Noninvasive polygraphic records were used to evaluate the function of the heart. The administration of daunorubicin induced changes especially in levels of protein (decrease in total protein and albumin) and of some ions (decrease in calcium, magnesium and phosphorus) as well as in hematological parameters (decrease in erythrocytes, leukocytes and thrombocytes). The results obtained correlate with data on mechanisms of daunorubicin toxicity.
