Interaction of bromine with iodine in the rat thyroid gland at enhanced bromide intake
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
8909694
DOI
10.1007/bf02784432
Knihovny.cz E-zdroje
- MeSH
- brom metabolismus farmakokinetika MeSH
- bromidy aplikace a dávkování metabolismus farmakokinetika MeSH
- chlor metabolismus farmakokinetika MeSH
- jod metabolismus farmakokinetika MeSH
- krysa rodu Rattus MeSH
- lékové interakce MeSH
- potkani Wistar MeSH
- štítná žláza metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- brom MeSH
- bromidy MeSH
- chlor MeSH
- jod MeSH
In experiments with rats, we have found that at enhanced intake of bromide, bromine does not replace chlorine in the thyroid; it replaces iodine. Under our experimental conditions, more than one-third of the iodine content in the thyroid was replaced by bromine. In the thyroid, bromine probably remained in the form of bromide and, in proportional to its increased concentration, the production of iodinated thyronines decreased, with the sum of the iodine and bromine concentrations being constant at the value of 20.51 +/- 1.16 mumol/g dry wt of the thyroid. In contrast to other organs, the biological behavior of bromine in the thyroid is not similar to the biological behavior of chlorine but resembles more that of iodine.
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