Cytokine profile in autosomal dominant polycystic kidney disease
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
9090470
DOI
10.1080/15216549700201651
Knihovny.cz E-zdroje
- MeSH
- cévní buněčněadhezivní molekula-1 krev MeSH
- cytokiny krev MeSH
- dospělí MeSH
- interleukin-1 krev MeSH
- interleukin-6 krev MeSH
- interleukin-8 krev MeSH
- lidé MeSH
- mezibuněčná adhezivní molekula-1 krev MeSH
- polycystické ledviny autozomálně dominantní krev MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- cévní buněčněadhezivní molekula-1 MeSH
- cytokiny MeSH
- interleukin-1 MeSH
- interleukin-6 MeSH
- interleukin-8 MeSH
- mezibuněčná adhezivní molekula-1 MeSH
To elucidate the pathogenetic mechanism of renal parenchymal injury in autosomal dominant polycystic kidney disease (ADPKD) patients, typically characterized by renal cystic changes paralleled by interstitial inflammation and gradual fibrotic changes, the role of selected inflammatory mediators was evaluated in a group of ADPKD patients with normal glomerular filtration rate. The plasma concentrations of IL-6, IL-8, ICAM-1 and VCAM-1 (which may reflect systemic response to inflammation/infection) were increased in the ADPKD patient group. Coupled with decreased urinary excretion of the IL-1 receptor antagonist (which exerts an anti-inflammatory role), these results suggest that even in overt infection free status, the proinflammatory system is more activated and anti-inflammatory defence system weakened in ADPKD subjects. Our data support the current view that cytokines are candidate contributors to pathogenesis of ADPKD.
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