Changes in cyclosporine A kinetics after experimental reduction of renal parenchyma
Language English Country France Media print
Document type Journal Article
PubMed
9358200
DOI
10.1007/bf03189808
Knihovny.cz E-resources
- MeSH
- Time Factors MeSH
- Cyclosporine blood pharmacokinetics MeSH
- Immunosuppressive Agents blood pharmacokinetics MeSH
- Rats MeSH
- Kidney metabolism MeSH
- Nephrectomy methods MeSH
- Renal Insufficiency metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cyclosporine MeSH
- Immunosuppressive Agents MeSH
Experimental chronic renal insufficiency (produced by 5/6 ablation of renal parenchyma) is associated with changes in the kinetics of oral (intragastric) cyclosporine A (CyA). Compared with animals with intact renal parenchyma, significantly lower levels of CyA are reached under these conditions. The factors responsible for reduced CyA availability under these conditions have not yet been identified.
