Výskyt prostatickej intraepiteliálnej neoplázie v materiáli získanom punkcnou biopsiou prostaty a jej klinický význam
[Occurrence of prostatic intraepithelial neoplasia in needle biopsy of the prostate and its clinical significance]
Language Slovak Country Czech Republic Media print
Document type English Abstract, Journal Article
PubMed
9471772
- MeSH
- Biopsy, Needle * MeSH
- Middle Aged MeSH
- Humans MeSH
- Prostatic Neoplasms diagnosis pathology MeSH
- Prostate pathology MeSH
- Prostatic Intraepithelial Neoplasia diagnosis pathology MeSH
- Prostate-Specific Antigen blood MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Names of Substances
- Prostate-Specific Antigen MeSH
From March 1994 to September 1996 485 patients of median age 67 years (range 49-82) underwent transrectal prostate needle biopsy at the Urological Clinic JLF UK in Martin. PIN was detected in 31 (6.4%) patients. Median age of patients with PIN was 67 years (range 58-75). There were 21 (68%) patients with low-grade PIN and 10 (32%) patients with high-grade PIN. In this group concomitant invasive cancer of the prostate was detected in 6 (19.4%) patients with PIN, of whom 5 (16.0%) had high-grade PIN and 1 (3.4%) nad low-grade PIN. Median concentration of PSA in patients with PIN was 9.1 ng/ml (range 1.3-85 ng/ml), significantly higher (p < 0.001) than PSA concentration in patients with BPH. We did not find significant differences between PSA concentrations in patients with PIN and in those with prostate cancer (p = 0.77). In conclusion we recommend clinical management of patients newly diagnosed with PIN.
