Význam volných radikálů v patogenezi revmatických chorob a moznosti snízení jejich patogenního působení
[Significance of free radicals in the pathogenesis of rheumatic diseases and possibilities of decreasing their pathogenic effects]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article, Research Support, Non-U.S. Gov't
PubMed
10422513
- MeSH
- Arthritis physiopathology MeSH
- Drug Combinations MeSH
- Humans MeSH
- Selenium therapeutic use MeSH
- Superoxides metabolism MeSH
- Vitamins therapeutic use MeSH
- Free Radicals metabolism MeSH
- Zinc therapeutic use MeSH
- Check Tag
- Humans MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Drug Combinations MeSH
- Selenium MeSH
- Superoxides MeSH
- Vitamins MeSH
- Free Radicals MeSH
- Zinc MeSH
The authors present the result of their work where they provide evidence that in inflammatory and degenerative diseases the break-down on superoxide in inadequate. This oxygen radicals and its metabolites play a significant role in the pathogenesis of these diseases. The authors revealed a severe defect in superoxide degeneration in particular in articular exudates of patients with active synovitis. Administration of the preparation Selzink-Plus of PRO.MED.CS Co. Prague which contains selenium, zinc, beta-cyrotene, vitamin C and E along with antirheumatic treatment improves according to the authors the breakdown of superoxide and its metabolites and improves thus the patient's prognosis. Long-term administration of the preparation seems to produce even better results.
