Antimeningococcal herd immunity in the Czech Republic--influence of an emerging clone, Neisseria meningitidis ET-15/37
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
10579437
PubMed Central
PMC2810749
DOI
10.1017/s095026889900285x
Knihovny.cz E-resources
- MeSH
- Antigens, Bacterial blood MeSH
- Child MeSH
- Adult MeSH
- Phenotype MeSH
- Infant MeSH
- Middle Aged MeSH
- Humans MeSH
- Meningococcal Infections epidemiology immunology MeSH
- Adolescent MeSH
- Neisseria meningitidis classification immunology MeSH
- Child, Preschool MeSH
- Carrier State MeSH
- Prevalence MeSH
- Immunity, Innate MeSH
- Seroepidemiologic Studies MeSH
- Age Factors MeSH
- Age Distribution MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Infant MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Child, Preschool MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic epidemiology MeSH
- Names of Substances
- Antigens, Bacterial MeSH
For many years, invasive meningococcal disease in the Czech Republic occurred sporadically and was caused mainly by meningococci of serogroup B. In 1993, when a new clone (ET-15/37) emerged, the only phenotype found was C:2a:P1.2,5. In 1995, an antigenic variation of the ET-15/37 clone, B:2a:P1.2,5, occurred. The results of immunological surveys conducted in 1989 and 1996 were compared. A significantly higher proportion of 1996 sera than those collected in 1989 showed bactericidal antibodies against N. meningitidis B:2a:P1.2,5 (19.7 vs. 5.1%) and N. meningitidis C:2a:P1.2,5 (15.9 vs. 7.4%), consistent with increased herd immunity due to the spread of the new clone in the Czech Republic. There were differences in the age distribution of the positive sera.
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