Antagonisté excitacních aminokyselin a potenciace korových evokovaných potenciálů
[Excitatory amino acid antagonists and potentiation of cortical evoked potentials]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article, Research Support, Non-U.S. Gov't
PubMed
10860126
- MeSH
- Receptors, AMPA antagonists & inhibitors MeSH
- Excitatory Amino Acid Antagonists pharmacology MeSH
- Quinoxalines pharmacology MeSH
- Dizocilpine Maleate pharmacology MeSH
- Evoked Potentials drug effects MeSH
- Glutamates MeSH
- Rats MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline MeSH Browser
- Receptors, AMPA MeSH
- Excitatory Amino Acid Antagonists MeSH
- Quinoxalines MeSH
- Dizocilpine Maleate MeSH
- Glutamates MeSH
- glutamic acid diethyl ester MeSH Browser
Changes of evoked potentials under the influence of NBQX (a non-NMDA receptor antagonist), MK-801 (a NMDA receptor antagonist) and GDEE (a nonselective antagonist of glutamate receptor) were studied. GDEE augmented potentiation and was marked progression of potentiation with increasing number of stimuli. There was no potentiation of responses in relation to the number of stimulus in a series in experiments with both MK-801 and NBQX. Interpretation of results with NBQX and MK-801 is difficult.
