Mutagenicity of natural anthraquinones from Rubia tinctorum in the Drosophila wing spot test
Jazyk angličtina Země Německo Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
11301857
DOI
10.1055/s-2001-11498
Knihovny.cz E-zdroje
- MeSH
- anthrachinony izolace a purifikace farmakologie toxicita MeSH
- Drosophila melanogaster účinky léků genetika růst a vývoj MeSH
- kořeny rostlin chemie MeSH
- křídla zvířecí účinky léků MeSH
- larva účinky léků genetika MeSH
- léčivé rostliny chemie MeSH
- molekulární struktura MeSH
- mutageny izolace a purifikace farmakologie toxicita MeSH
- pyrany izolace a purifikace farmakologie toxicita MeSH
- rekombinace genetická účinky léků MeSH
- Rubiaceae chemie MeSH
- testy genotoxicity MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- anthrachinony MeSH
- mutageny MeSH
- pyrany MeSH
- rubimaillin MeSH Prohlížeč
Mutagenicity of anthraquinone aglycones from Rubia tinctorum L. (Rubiaceae) was examined using the somatic mutation and recombination test in Drosophila melanogaster. Larvae heterozygous for recessive wing trichome mutations, multiple wing hairs (mwh), and flare (flr3) were exposed to test compounds and wings of emerged mwh/flr3 females were inspected for the presence of phenotypically mutant mosaic spots. No significant increase in the frequency of mutant spots was observed after the treatment of Drosophila larvae with pure alizarin, xanthopurpurin, and lucidin, or with the crude mixture of anthraquinone aglycones. In contrast, the naphthohydroquinone mollugin induced mainly single spots that can originate either from somatic mutation or from mitotic recombination. Twin spots, consisting of both the mwh and flr3 subclones and originating exclusively from mitotic recombination, were also enhanced, but the increase was only marginally significant. We suggest that mollugin exhibits both the mutagenic and recombinagenic activities.
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