Cell inactivation by ionizing particles and the shapes of survival curves
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11343427
DOI
10.1006/jtbi.2001.2283
PII: S0022-5193(01)92283-0
Knihovny.cz E-resources
- MeSH
- Models, Biological MeSH
- Cell Nucleus radiation effects MeSH
- Cell Line MeSH
- Cells radiation effects MeSH
- Deuterium MeSH
- Helium MeSH
- Radiation, Ionizing * MeSH
- Probability MeSH
- Protons MeSH
- Cell Survival MeSH
- Dose-Response Relationship, Radiation MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Deuterium MeSH
- Helium MeSH
- Protons MeSH
Recent experiments concerning the survival of monolayer cells irradiated by different parts of ion Bragg peaks opened a way to a deeper mechanistic understanding of cell inactivation. A new theoretical formula for survival curves has been derived reflecting two basic phases of the given mechanism, i.e. energy transfer to a cell nucleus and subsequent biological effect (depending on the amount of imparted energy). The survival ratio for a given dose has been expressed as a function of inactivation probabilities of individual cells after different numbers of nucleus hits (a given amount of energy being transferred to a cell nucleus in each ion traversal). Having used the experimental data for V79 cells irradiated by protons, deuterons and helium ions in different parts of Bragg peaks preliminary values of these inactivation probabilities for individual cells at different LET values have been established.
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