A DNA polymerase epsilon inhibitor activates the ribo and deoxyribo modes of primase expression and induces a unique phenomenon of primer accumulation
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články
PubMed
11557057
DOI
10.1016/s0014-5793(01)02808-3
PII: S0014579301028083
Knihovny.cz E-zdroje
- MeSH
- bisfosfonáty farmakologie MeSH
- deoxyribonukleotidy metabolismus MeSH
- DNA primery metabolismus MeSH
- DNA-polymerasa I metabolismus MeSH
- DNA-polymerasa II antagonisté a inhibitory MeSH
- DNA-primasa účinky léků metabolismus MeSH
- inhibitory enzymů farmakologie MeSH
- mimosin metabolismus MeSH
- ribonukleotidy metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- bisfosfonáty MeSH
- carbonyldiphosphonate MeSH Prohlížeč
- deoxyribonukleotidy MeSH
- DNA primery MeSH
- DNA-polymerasa I MeSH
- DNA-polymerasa II MeSH
- DNA-primasa MeSH
- inhibitory enzymů MeSH
- mimosin MeSH
- ribonukleotidy MeSH
Carbonyldiphosphonate (COMDP), a selective inhibitor of DNA polymerase (pol) epsilon, strongly stimulates expression of the ribo and deoxyribo modes of primase (Pr) activities of the Pr-DNA pol alpha enzyme complex associated with special cytoplasmic nucleoprotein complexes of chicken leukemic myeloblasts [J. Ríman and A. Sulová, Acta Virol. 41 (1997) 181-214]. Besides stimulation, COMDP uncouples the Pr activities from those of DNA pol alpha, inducing in this way a unique phenomenon of accumulation of primers of basic length. In the presence of dNTPs, the COMDP effect is counteracted by excess of mimosine. The mutually exclusive effects of these agents are discussed.
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